T Cells Regulate Peripheral Naive Mature B Cell Survival by Cell–Cell Contact Mediated through SLAMF6 and SAP

The control of lymphoid homeostasis is the result of a very fine balance between lymphocyte production, proliferation, and apoptosis. In this study, we focused on the role of T cells in the maintenance/survival of the mature naive peripheral B cell population. We show that naive B and T cells intera...

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Bibliographic Details
Published in:The Journal of immunology (1950) 2017-10, Vol.199 (8), p.2745-2757
Main Authors: Radomir, Lihi, Cohen, Sivan, Kramer, Matthias P, Bakos, Eszter, Lewinsky, Hadas, Barak, Avital, Porat, Ziv, Bucala, Richard, Stepensky, Polina, Becker-Herman, Shirly, Shachar, Idit
Format: Article
Language:English
Subjects:
Adaptor proteins
Animals
Antibodies, Blocking - administration & dosage
Apoptosis
B-Lymphocyte Subsets - physiology
B-Lymphocytes - physiology
Blood Cells - physiology
CD150 antigen
Cell activation
Cell Communication
Cell Differentiation
Cell Proliferation
Cell Survival
Cells, Cultured
Homeostasis
Humans
Leukocyte migration
Lymphocyte receptors
Lymphocytes
Lymphocytes B
Lymphocytes T
Lymphoproliferative Disorders - immunology
Macrophage migration inhibitory factor
Mice
Mice, Inbred C57BL
Mice, Knockout
RNA, Small Interfering - genetics
SAP protein
Signaling Lymphocytic Activation Molecule Associated Protein - genetics
Signaling Lymphocytic Activation Molecule Associated Protein - metabolism
Signaling Lymphocytic Activation Molecule Family - genetics
Signaling Lymphocytic Activation Molecule Family - metabolism
T-Lymphocytes - physiology
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