High-fat-diet-induced obesity upregulates the expression of lymphoid chemokines and promotes the formation of gastric lymphoid follicles after Helicobacter suis infection

Abstract Helicobacter suis colonizes the stomachs of a variety of animals, including humans, and is more likely than other Helicobacter species to induce gastric mucosa-associated lymphoid tissue lymphoma. Obesity is a low-grade chronic inflammatory state in which the induction of a chemokine networ...

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Bibliographic Details
Published in:Pathogens and disease 2017-11, Vol.75 (8)
Main Authors: Zhao, Wen-jun, Tian, Zi-bin, Yao, Shan-shan, Yu, Ya-nan, Zhang, Cui-ping, Li, Xiao-yu, Mao, Tao, Jing, Xue, Ding, Xue-li, Yang, Ruo-ming, Liu, Ya-qian, Zhang, Shuai-qing, Yang, Lin
Format: Article
Language:English
Subjects:
Animals
Bacterial infections
Chemokines
Chemokines - genetics
Chemokines - metabolism
Diet
Diet, High-Fat - adverse effects
Follicles
Gastric mucosa
Gastritis - microbiology
Gene Expression Regulation - drug effects
Helicobacter heilmannii
Helicobacter Infections - microbiology
Helicobacter Infections - pathology
Helicobacter suis
High fat diet
Infections
Inflammation
Lymphoma
Malt
Mice
Mucosal-associated lymphoid tissue
NF-κB protein
Obesity
Obesity - chemically induced
Pathogenesis
Signal transduction
Signaling
Stomach
Stomach - microbiology
Stomach - pathology
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Summary:Abstract Helicobacter suis colonizes the stomachs of a variety of animals, including humans, and is more likely than other Helicobacter species to induce gastric mucosa-associated lymphoid tissue lymphoma. Obesity is a low-grade chronic inflammatory state in which the induction of a chemokine network contributes to a variety of diseases. However, the effect of obesity on the development of gastric MALT in the presence of H. suis infection remains unclear. Here, we reveal that high-fat-diet-induced obesity upregulates the expression of lymphoid chemokines in the stomach and accelerates the H. suis infection-induced formation of gastric lymphoid follicles, potentially via a mechanism that involves the activation of the nuclear factor kappa B (NF-κB) signaling pathway. These findings provide novel insight into the pathogenesis of obesity-related diseases, especially those induced by Helicobacter infection. Obesity promotes the formation of gastric MALT induced by Helicobacter suis.
ISSN:2049-632X
2049-632X
DOI:10.1093/femspd/ftx101