Reduced risk of peanut sensitization following exposure through breast-feeding and early peanut introduction

Recent trials have shown that avoiding peanuts during infancy increases the risk of peanut allergy; however, these studies did not address maternal peanut consumption. We sought to investigate the relationship between maternal peanut consumption while breast-feeding, timing of direct peanut introduc...

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2018-02, Vol.141 (2), p.620-625.e1
Main Authors: Pitt, Tracy J., Becker, Allan B., Chan-Yeung, Moira, Chan, Edmond S., Watson, Wade T.A., Chooniedass, Rishma, Azad, Meghan B.
Format: Article
Language:English
Subjects:
Age
Allergies
Asthma
Atopy
Babies
Breast
Breast-feeding
Breastfeeding & lactation
Children
Eggs
Exposure
Feeding
Food allergies
Incidence
lactation
maternal peanut consumption
Nutrition research
Nuts
peanut allergy
peanut sensitization
Peanuts
Pediatrics
Prevention
Questionnaires
Risk reduction
Secondary analysis
Skin tests
timing of peanut introduction
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Summary:Recent trials have shown that avoiding peanuts during infancy increases the risk of peanut allergy; however, these studies did not address maternal peanut consumption. We sought to investigate the relationship between maternal peanut consumption while breast-feeding, timing of direct peanut introduction, and peanut sensitization at age 7 years. Secondary analysis of a nested cohort within the 1995 Canadian Asthma Primary Prevention Study intervention study was performed. Breast-feeding and maternal and infant peanut consumption were captured by repeated questionnaires during infancy. Skin prick testing for peanut sensitization was performed at age 7 years. Overall, 58.2% of mothers consumed peanuts while breast-feeding and 22.5% directly introduced peanuts to their infant by 12 months. At 7 years, 9.4% of children were sensitized to peanuts. The lowest incidence (1.7%) was observed among children whose mothers consumed peanuts while breast-feeding and directly introduced peanuts before 12 months. Incidence was significantly higher (P 
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2017.06.024