Significance of Serum and Ascitic Fluid C-Reactive Protein in Differential Diagnosis of Benign and Malignant Ascites

Background The values of C-reactive protein (CRP) can prove useful in determining disease progress. Because of synthesis by the liver, production of CRP in response to inflammation may be attenuated in patients with liver dysfunction. This may result in differences interpreting CRP levels in patient...

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Bibliographic Details
Published in:Digestive diseases and sciences 2014-10, Vol.59 (10), p.2588-2593
Main Authors: Yuksel, Ilhami, Karaahmet, Fatih, Coskun, Yusuf, Kılıncalp, Serta, Hamamci, Mevlut, Akinci, Hakan, Ustun, Yusuf, Simsek, Zahide, Erarslan, Elife, Coban, Sahin
Format: Article
Language:English
Subjects:
Adult
Aged
Ascites
Ascites - diagnosis
Ascites - pathology
Ascitic Fluid - chemistry
Biochemistry
C-reactive protein
C-Reactive Protein - chemistry
Development and progression
Diagnosis
Female
Gastroenterology
Hepatology
Humans
Hypertension
Hypertension, Portal - diagnosis
Inflammation
Liver
Liver Cirrhosis - diagnosis
Liver diseases
Liver Neoplasms - diagnosis
Male
Medical research
Medicine
Medicine & Public Health
Medicine, Experimental
Middle Aged
Oncology
Original Article
Transplant Surgery
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Summary:Background The values of C-reactive protein (CRP) can prove useful in determining disease progress. Because of synthesis by the liver, production of CRP in response to inflammation may be attenuated in patients with liver dysfunction. This may result in differences interpreting CRP levels in patient with portal and non-portal hypertension ascites. Aim The aim of the present study is to assess discriminant value of serum and ascitic fluid CRP, which is easily accessible and inexpensive laboratory marker of inflammation, concentrations for diagnosis of underlying cause of ascites. Methods This prospective study was conducted at Dıskapı Yıldırım Beyazıt Educational and Research Hospital Department of Gastroenterology. Patients with ascites were further divided into two subgroups based on underlying cause of ascites: Group 1, patient with ascites due to portal hypertensive etiology (high-gradient ascites); Group 2, patient with ascites due to non-portal hypertensive etiology (low-gradient ascites). Results A total of 91 patients fulfilling the criteria for a diagnosis of ascites were enrolled in the study. Of these patients, 50 had proven (Group 1) ascites due to portal hypertensive etiology (high-gradient ascites) and 41 had clinical (Group 2) ascites due to non-portal hypertensive etiology (low-gradient ascites). Mean baseline serum and ascites levels of CRP were significantly higher in Group 2 compared to those in Group 1 ( p  = 0.021, p  = 
ISSN:0163-2116
1573-2568
DOI:10.1007/s10620-014-3205-4