Vitamin D Status Is Associated with Intestinal Inflammation as Measured by Fecal Calprotectin in Crohn’s Disease in Clinical Remission

Background Vitamin D, as potential immune modulator, has been implicated as an environmental risk factor for Crohn’s disease (CD). Vitamin D status may be associated with disease risk, severity, activity, and progression. While associations between circulating 25OHD and markers of disease activity a...

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Bibliographic Details
Published in:Digestive diseases and sciences 2015-08, Vol.60 (8), p.2427-2435
Main Authors: Raftery, Tara, Merrick, Megan, Healy, Martin, Mahmud, Nasir, O’Morain, Colm, Smith, Sinead, McNamara, Deirdre, O’Sullivan, Maria
Format: Article
Language:English
Subjects:
Adult
Alfacalcidol
Biochemistry
Biomarkers - metabolism
C-Reactive Protein - metabolism
Calcifediol
Comorbidity
Crohn Disease - epidemiology
Crohn Disease - metabolism
Crohn Disease - pathology
Cross-Sectional Studies
Disease Progression
Enzyme-Linked Immunosorbent Assay
Feces - chemistry
Female
Gastroenterology
Hepatology
Humans
Inflammation
Leukocyte L1 Antigen Complex - metabolism
Male
Measurement
Medicine
Medicine & Public Health
Middle Aged
Oncology
Original Article
Pneumoviridae
Risk factors
Transplant Surgery
Vitamin D
Vitamin D - analogs & derivatives
Vitamin D - blood
Vitamin D Deficiency - epidemiology
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Summary:Background Vitamin D, as potential immune modulator, has been implicated as an environmental risk factor for Crohn’s disease (CD). Vitamin D status may be associated with disease risk, severity, activity, and progression. While associations between circulating 25OHD and markers of disease activity and inflammation in CD have been reported, the results are inconsistent. Aim To determine the association between vitamin D status and markers of disease activity and inflammation in CD. Methods One hundred and nineteen CD patients’ active and inactive diseases were enrolled in the cross-sectional study. Subject demographics and clinical data were collected. A serum sample was collected for 25OHD and CRP analysis, and a stool sample was collected for fecal calprotectin (FC) measurement. Results The mean serum 25OHD concentration of the group was 59.8 (24.9) nmol/L. After controlling for confounding variables, serum 25OHD inversely correlated with FC ( r  = −0.207, P  = 0.030), particularly among those in clinical remission ( r  = −0.242, P  = 0.022). The association between FC and 25OHD was further confirmed by linear regression ( r  = 31.3 %, P  
ISSN:0163-2116
1573-2568
DOI:10.1007/s10620-015-3620-1