Arsenic in Drinking Water and Bladder Cancer Mortality in the United States: An Analysis Based on 133 U.S. Counties and 30 Years of Observation

This study analyzes the relationship between arsenic exposure through dunking water and bladder cancer mortality. The county-specific white male bladder cancer mortality data (1950-1979) and county-specific groundwater arsenic concentration data were obtained for 133 U.S. counties known to be exclus...

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Bibliographic Details
Published in:Journal of occupational and environmental medicine 2004-03, Vol.46 (3), p.298-306
Main Authors: Lamm, Steven H., Engel, Arnold, Kruse, Michael B., Feinleib, Manning, Byrd, Daniel M., Lai, Shenghan, Wilson, Richard
Format: Article
Language:English
Subjects:
Adult
Aged
Arsenic - toxicity
Arsenic content
Biological and medical sciences
Cancer
Chemical and industrial products toxicology. Toxic occupational diseases
Drinking
Drinking water
Groundwater
Health risk assessment
Humans
Longitudinal Studies
Male
Medical sciences
Men
Metals and various inorganic compounds
Middle Aged
Mortality
ORIGINAL ARTICLES
Regression Analysis
Toxicology
United States - epidemiology
Urinary Bladder Neoplasms - chemically induced
Urinary Bladder Neoplasms - mortality
Water Pollutants - toxicity
Water Supply
White people
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Summary:This study analyzes the relationship between arsenic exposure through dunking water and bladder cancer mortality. The county-specific white male bladder cancer mortality data (1950-1979) and county-specific groundwater arsenic concentration data were obtained for 133 U.S. counties known to be exclusively dependent on groundwater for their public dunking water supply. No arsenic-related increase in bladder cancer mortality was found over the exposure range of 3 to 60 µg/L using stratified analysis and regression analyses (both unweighted and weighted by county population and using both mean and median arsenic concentrations). These results, which provide a direct estimate of arsenic-related cancer risk for U.S. residents, exclude the National Research Council's 2001 risk estimate that was based on Southwest Taiwan data and required adjusting for differences between the body mass and water consumption rates of U.S. and Taiwanese residents.
ISSN:1076-2752
1536-5948
DOI:10.1097/01.jom.0000116801.67556.8f