Prognostic impact of unrecognized myocardial scar in the non-culprit territories by cardiac magnetic resonance imaging in patients with acute myocardial infarction

Abstract Aims Unrecognized myocardial scar by late gadolinium enhancement (LGE) magnetic resonance imaging (MRI) is strongly associated with cardiac event in patients with stable coronary artery disease. The purpose of this study was to evaluate the prognostic impact of unrecognized non-infarct-rela...

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Bibliographic Details
Published in:European heart journal cardiovascular imaging 2018-01, Vol.19 (1), p.108-116
Main Authors: Omori, Taku, Kurita, Tairo, Dohi, Kaoru, Takasaki, Akihiro, Nakata, Tomoyuki, Nakamori, Shiro, Fujimoto, Naoki, Kitagawa, Kakuya, Hoshino, Kozo, Tanigawa, Takashi, Sakuma, Hajime, Ito, Masaaki
Format: Article
Language:English
Subjects:
Aged
Cicatrix - diagnostic imaging
Cicatrix - pathology
Cohort Studies
Coronary Angiography - methods
Diagnostic Errors
Female
Gadolinium
Humans
Kaplan-Meier Estimate
Magnetic Resonance Imaging, Cine - methods
Male
Middle Aged
Multivariate Analysis
Myocardial Infarction - diagnostic imaging
Myocardial Infarction - mortality
Myocardial Infarction - pathology
Myocardial Infarction - surgery
Percutaneous Coronary Intervention - methods
Prognosis
Proportional Hazards Models
Radiographic Image Enhancement - methods
Retrospective Studies
Risk Assessment
Severity of Illness Index
Symptom Assessment
Treatment Outcome
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Summary:Abstract Aims Unrecognized myocardial scar by late gadolinium enhancement (LGE) magnetic resonance imaging (MRI) is strongly associated with cardiac event in patients with stable coronary artery disease. The purpose of this study was to evaluate the prognostic impact of unrecognized non-infarct-related LGE (non-IR-LGE) in patients with acute myocardial infarction (AMI). Methods and results We studied 269 patients with a first clinical episode of AMI underwent cardiac MRI within 6 weeks after onset (209 men; age, 66 ± 12 years). LGE, cine MRI and T2-weighted imaging were obtained to evaluate the presence and extent of LGE and to evaluate cardiac function. Major adverse cardiac events (MACE) were defined as cardiovascular death, non-fatal AMI, unstable angina requiring revascularization, fatal arrhythmia, and heart failure. Unrecognized non-IR LGE was observed in 13.0% of patients. During follow-up periods (median, 22 months; range, 3–95 months), 8.9% of patients experienced MACE in this study. In addition, 22.9% of patients with unrecognized non-IR LGE and 6.8% of patients without unrecognized non-IR-LGE experienced MACE (P 
ISSN:2047-2404
2047-2412
DOI:10.1093/ehjci/jex194