Plasma amino acid profile in major depressive disorder: Analyses in two independent case-control sample sets

Some amino acids act as neurotransmitters themselves, or are precursors of neurotransmitters. Previous studies reported inconsistent results regarding their changes in blood in major depressive disorder (MDD), which prompted us to examine plasma levels of amino acids and related molecules in two ind...

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Bibliographic Details
Published in:Journal of psychiatric research 2018-01, Vol.96, p.23-32
Main Authors: Ogawa, Shintaro, Koga, Norie, Hattori, Kotaro, Matsuo, Junko, Ota, Miho, Hori, Hiroaki, Sasayama, Daimei, Teraishi, Toshiya, Ishida, Ikki, Yoshida, Fuyuko, Yoshida, Sumiko, Noda, Takamasa, Higuchi, Teruhiko, Kunugi, Hiroshi
Format: Article
Language:English
Subjects:
Adult
Amino acids
Amino Acids - blood
Biomarkers - blood
Blood plasma
Case-Control Studies
Case-control study
Chromatography, High Pressure Liquid
Depressive Disorder, Major - blood
Depressive Disorder, Major - drug therapy
Female
Glutamate
Humans
Interview, Psychological
Logistic Models
Major depressive disorder
Male
Methionine
Psychiatric Status Rating Scales
Psychotropic Drugs - therapeutic use
ROC Curve
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Summary:Some amino acids act as neurotransmitters themselves, or are precursors of neurotransmitters. Previous studies reported inconsistent results regarding their changes in blood in major depressive disorder (MDD), which prompted us to examine plasma levels of amino acids and related molecules in two independent case-control sample sets. In total, 511 subjects were recruited. Sample set A consisted of 164 patients with MDD (147 currently depressed [dMDD]; 17 in remission, DSM-IV) and 217 healthy controls. Sample set B consisted of 65 patients (51 dMDD; 14 in remission) and 65 controls. Plasma amino acid levels were measured using high-performance liquid chromatography for set A and liquid chromatography/mass spectrometry for set B. We further analyzed the relationships between plasma amino acid levels and clinical variables. In sample set A, plasma asparagine, histidine+1-methylhistidine, methionine, phenylalanine, tryptophan, and tyrosine levels were decreased, while plasma glutamate and phosphoethanolamine were elevated in dMDD compared to controls (all P 
ISSN:0022-3956
1879-1379
DOI:10.1016/j.jpsychires.2017.09.014