Peripheral versus central effect of intravenous moxonidine on rat carotid sinus baroreflex-mediated sympathetic arterial pressure regulation

• Published in: Life sciences (1973) 2017-12, Vol.190, p.103-109
• Main Authors: Kawada, Toru, Shimizu, Shuji, Yamamoto, Hiromi, Miyamoto, Tadayoshi, Shishido, Toshiaki, Sugimachi, Masaru
• Format: Article
• Language: English
• Subjects: Adrenergic receptors; Animals; Antihypertensive Agents - pharmacology; Antihypertensives; Arterial Pressure - drug effects; Baroreceptors; Baroreflex - drug effects; Blood pressure; Carotid sinus; Carotid Sinus - drug effects; Carotid Sinus - metabolism; Carotid sinus baroreflex; Clinical trials; Drug delivery systems; Drugs; Imidazoles - administration & dosage; Imidazoles - pharmacology; Imidazoline; Imidazoline agonist; Imidazoline receptors; Infusions, Intravenous; Injections, Intravenous; Intravenous administration; Male; Mercury; Moxonidine; Open-loop systems analysis; Rats; Rats, Wistar; Receptors; Receptors (physiology); Reflexes; Rodents; Selectivity; Sinus; Sympathetic nerve activity; Sympathetic Nervous System - drug effects; Sympathetic Nervous System - metabolism; Vasoconstriction - drug effects
• ISSN: 0024-3205; 1879-0631
• DOI: 10.1016/j.lfs.2017.09.038

Moxonidine is a centrally acting antihypertensive agent with a selectivity to I1-imidazoline receptors higher than that to α2-adrenergic receptors. The present study aimed to quantify a peripheral effect of moxonidine on carotid sinus baroreflex-mediated sympathetic arterial pressure (AP) regulation separately from its central effect. In eight anesthetized Wistar rats, changes in efferent sympathetic nerve activity (SNA) and AP in response to a carotid sinus pressure input were compared before and during an intravenous administration of moxonidine (100μgkg−1 bolus followed by a continuous infusion at 200μg·kg−1·h−1). Moxonidine significantly narrowed the range of the AP response (55.3±5.8 to 39.1±6.1mmHg, P