Iron/iron oxide core-shell nanoclusters for biomedical applications

Issue Title: Davos Special Issue: Nanoparticles from the Vapor Phase Synthesis with Chemical and Biochemical Applications Biocompatible magnetic nanoparticles have been found promising in several biomedical applications for tagging, imaging, sensing and separation in recent years. Most magnetic part...

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Bibliographic Details
Published in:Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology 2006-08, Vol.8 (3-4), p.489-496
Main Authors: Qiang, You, Antony, Jiji, Sharma, Amit, Nutting, Joseph, Sikes, Daniel, Meyer, Daniel
Format: Article
Language:English
Subjects:
Chemical reactions
Iron oxides
Magnetic fields
Magnetism
Nanoparticles
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Summary:Issue Title: Davos Special Issue: Nanoparticles from the Vapor Phase Synthesis with Chemical and Biochemical Applications Biocompatible magnetic nanoparticles have been found promising in several biomedical applications for tagging, imaging, sensing and separation in recent years. Most magnetic particles or beads currently used in biomedical applications are based on ferromagnetic iron oxides with very low specific magnetic moments of about 20-30 emu/g. Here we report a new approach to synthesize monodispersed core-shell nanostructured clusters with high specific magnetic moments above 200 emu/g. Iron nanoclusters with monodispersive size of diameters from 2 nm to 100 nm are produced by our newly developed nanocluster source and go to a deposition chamber, where a chemical reaction starts, and the nanoclusters are coated with iron oxides. HRTEM Images show the coatings are very uniform and stable. The core-shell nanoclusters are superparamagnetic at room temperature for sizes less than 15 nm, and then become ferromagnetic when the cluster size increases. The specific magnetic moment of core-shell nanoclusters is size dependent, and increases rapidly from about 80 emu/g at the cluster size of around 3 nm to over 200 emu/g up to the size of 100 nm. The use of high magnetic moment nanoclusters for biomedical applications could dramatically enhance the contrast for MRI, reduce the concentration of magnetic particle needs for cell separation, or make drug delivery possible with much lower magnetic field gradients[PUBLICATION ABSTRACT]
ISSN:1388-0764
1572-896X
DOI:10.1007/s11051-005-9011-3