AMPK: guardian of metabolism and mitochondrial homeostasis

Key Points AMP-activated protein kinase (AMPK) is a highly conserved sensor of low intracellular ATP levels that is rapidly activated after nearly all mitochondrial stresses, even those that do not disrupt the mitochondrial membrane potential. Upon changes in the ATP-to-AMP ratio, AMPK is activated...

Full description

Saved in:

Bibliographic Details
Published in:	Nature reviews. Molecular cell biology 2018-02, Vol.19 (2), p.121-135
Main Authors:	Herzig, Sébastien, Shaw, Reuben J.
Format:	Article
Language:	English
Subjects:	631/443/319 631/80/642/333 631/80/642/333/1465 631/80/86 631/80/86/2369 Adenosine Triphosphatases - metabolism Adenosine Triphosphatases - physiology AMP AMP-activated protein kinase AMP-Activated Protein Kinases - metabolism AMP-Activated Protein Kinases - physiology Animals Autophagy Biochemistry Cancer Research Catabolism Cell Biology Cell metabolism Developmental Biology Energy Metabolism Eukaryotes Genetic aspects Glucose metabolism Health aspects Homeostasis Humans Kinases Life Sciences Lipid metabolism Metabolism Mitochondria Mitochondria - metabolism Mitochondria - physiology Nutrient availability Phagocytosis Phosphorylation Properties Protein kinases Protein-Serine-Threonine Kinases - metabolism Protein-serine/threonine kinase review-article Stem Cells Substrates
Citations:	Items that this one cites Items that cite this one
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!