Transient cervical nerve root compression modulates pain: Load thresholds for allodynia and sustained changes in spinal neuropeptide expression

Nerve root compression produces chronic pain and altered spinal neuropeptide expression. This study utilized controlled transient loading in a rat model of painful cervical nerve root compression to investigate the dependence of mechanical allodynia on load magnitude. Injury loads (0–110 mN) were ap...

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Bibliographic Details
Published in:Journal of biomechanics 2008-01, Vol.41 (3), p.677-685
Main Authors: Hubbard, Raymond D., Chen, Zhen, Winkelstein, Beth A.
Format: Article
Language:English
Subjects:
Animals
Calcitonin Gene-Related Peptide - biosynthesis
Cervical
Compressive Strength
Disease Models, Animal
Gene Expression Regulation
Humans
Load
Neck pain
Neck Pain - metabolism
Neck Pain - pathology
Nerve Compression Syndromes - metabolism
Nerve Compression Syndromes - pathology
Nerve root
Physical Medicine and Rehabilitation
Postoperative period
Rats
Rodents
Spinal cord
Sports injuries
Studies
Substance P - biosynthesis
Threshold
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