Protective role of epigallocatechin-3-gallate on arsenic induced testicular toxicity in Swiss albino mice

[Display omitted] Arsenic, often referred to as the king of poisons is carcinogenic in humans and animals. It affects multiorgan systems including reproduction. The present study was undertaken to explore the protective role of green tea compound, epigallocatechin-3-gallate (EGCG) on arsenic induced...

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Published in:Biomedicine & pharmacotherapy 2017-12, Vol.96, p.685-694
Main Authors: Guvvala, Pushpa Rani, Ravindra, Janivara Parameswaraiah, Rajani, Chukkath Vijayan, Sivaram, Muniandy, Selvaraju, Sellappan
Format: Article
Language:English
Subjects:
Animals
Antioxidants - metabolism
Arsenic
Arsenic - pharmacology
Catechin - analogs & derivatives
Catechin - pharmacology
EGCG
Glutathione - metabolism
Lipid peroxidation
Lipid Peroxidation - drug effects
Male
Malondialdehyde - metabolism
Membrane Potential, Mitochondrial - drug effects
Mice
Oxidative stress
Oxidative Stress - drug effects
Protective Agents - pharmacology
Reproduction - drug effects
Spermatogenesis
Spermatozoa function
Testis - drug effects
Testis - metabolism
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Summary:[Display omitted] Arsenic, often referred to as the king of poisons is carcinogenic in humans and animals. It affects multiorgan systems including reproduction. The present study was undertaken to explore the protective role of green tea compound, epigallocatechin-3-gallate (EGCG) on arsenic induced testicular toxicity in Swiss albino mice. Thirty two adult male mice were randomly assigned to four groups (n=8). Group I served as control without test chemical. The group II received arsenic (200ppm) through drinking water, group III received only EGCG (20mg/kgb.wt., intraperitoneally, alternate days) and group IV was administered arsenic+EGCG for 40days. Factorial experimental design was employed to assess the treatment effect. The EGCG restored arsenic induced decrements in epididymal sperm concentration, kinematic attributes (total motility, rapid, progressive motile, fast progressive, VSL, VAP, VCL, BCF, LIN, WOB, STR and Type A), structutal membrane integrity, functional membrane integrity and mitochondrial membrane potential. As evidenced by the histoarchitectural studies, the EGCG reversed the deleterious effects of arsenic on testicular malondialdehyde (p
ISSN:0753-3322
1950-6007
DOI:10.1016/j.biopha.2017.09.151