Pyrethroid pesticides and their metabolites in vacuum cleaner dust collected from homes and day-care centers

• Published in: Environmental research 2008-11, Vol.108 (3), p.271-279
• Main Authors: Starr, James, Graham, Stephen, Stout, Daniel, Andrews, Kim, Nishioka, Marcia
• Format: Article
• Language: English
• Subjects: Air; Biological and medical sciences; Biomarkers; Child; Child Day Care Centers; Degradation; Environmental Exposure; Environmental Monitoring - statistics & numerical data; Environmental pollutants toxicology; Gas Chromatography-Mass Spectrometry; Housing; Humans; Indoor dust; Medical sciences; Models, Biological; Molecular Structure; North Carolina; Ohio; Pesticide Residues - analysis; Pesticide Residues - chemistry; Pesticides - analysis; Pesticides - chemistry; Pesticides, fertilizers and other agrochemicals toxicology; Pyrethrins - analysis; Pyrethrins - chemistry; Pyrethroids; Toxicology
• ISSN: 0013-9351; 1096-0953
• DOI: 10.1016/j.envres.2008.07.022

Urinary metabolites of pyrethroid pesticides have been used as biomarkers to estimate human exposure to the parent insecticide. It is important to establish whether these markers are present in environments or media to which humans are exposed routinely. Failure to account for the contribution of pre-existing markers to urinary concentrations could result in risk assessments that overestimate exposure. The purpose of this study was to quantify the concentrations of 13 selected pyrethroid pesticides and their degradation products in samples of indoor dust that had been collected in vacuum cleaner bags during the children's total exposure to persistent pesticides and other persistent organic pollutants (CTEPP) study of homes and day cares in North Carolina and Ohio. Sieved contents of 85 vacuum cleaner bags were analyzed, and permethrin was found in all samples. Sixty-nine samples contained at least one additional pyrethroid, but none contained more than five pyrethroids in detectable concentrations. Resmethrin, prallethrin, and fenpropathrin were not detected in any samples, while 36 contained phenothrin. The median concentration of permethrin in the samples was 1454 ng/g of dust. Excluding permethrin, pyrethroid concentrations were typically less than or equal to 100 ng/g of dust. The majority of degradates were present in more than half of the dust samples, usually at concentrations of less than or equal to 100 ng/g of dust. For those pyrethroids with a characteristic oxydibenzene group, the cyclopropane degradates were present at higher concentrations than the corresponding benzoic acid moieties. Using urinary concentrations of these metabolites to model human exposure to the parent pyrethroids, may over-estimate risk due to the presence of pre-existing degradates in dust.