Frequency of inflammatory-like MR imaging findings in asymptomatic fingers of healthy volunteers

• Published in: Skeletal radiology 2018-02, Vol.47 (2), p.279-287
• Main Authors: Agten, Christoph A., Rosskopf, Andrea B., Jonczy, Maciej, Brunner, Florian, Pfirrmann, Christian W. A., Buck, Florian M.
• Format: Article
• Language: English
• Subjects: Animal bites; Arthritis; Bone marrow; Clinical trials; Comparative analysis; Correlation coefficients; Edema; Effusion; Finger; Fingers; Gadolinium; Imaging; Inflammation; Knee; Magnetic resonance imaging; Medical research; Medicine; Medicine & Public Health; Nuclear Medicine; Orthopedics; Pathology; Patients; Psoriasis; Psoriatic arthritis; Radiology; Rheumatoid arthritis; Rheumatoid factor; Rheumatology; Scientific Article; Sheaths; Tenosynovitis
• ISSN: 0364-2348; 1432-2161
• DOI: 10.1007/s00256-017-2808-1

Objective To describe the frequency of inflammatory-like findings on MR imaging in asymptomatic volunteers and compare them with patients with known rheumatoid arthritis and psoriatic arthritis. Materials and methods MR images of fingers in 42 asymptomatic volunteers and 33 patients with rheumatoid/psoriatic arthritis were analyzed. The Outcome Measures in Rheumatology Clinical Trials (OMERACT) Rheumatoid/Psoriatic Arthritis MRI Scoring System (RAMRIS/PsAMRIS) and tenosynovitis scoring system were used to assess: bone marrow edema (BME), erosions, tendon sheath fluid/tenosynovitis, joint effusion, and soft-tissue edema. Findings and scores were compared between volunteers and patients. Inter-reader agreement was calculated (intraclass correlation coefficients, ICC). Results In volunteers, tendon sheath fluid was very common in at least one location (42/42 volunteers for reader 1, 34/42 volunteers for reader 2). BME, erosions, joint effusion, and soft-tissue edema were absent (except one BME in the 3rd proximal phalanx for reader 1). Tendon sheath fluid scores in volunteers and tenosynovitis scores in patients were high (reader 1, 7.17 and 5.39; reader 2, 2.31 and 5.45). Overall, inter-reader agreement was substantial (ICC = 0.696–0.844), except for tendon sheath fluid (ICC = 0.258). Conclusion Fluid in the finger flexor tendon sheaths may be a normal finding and without gadolinium administration should not be interpreted as tenosynovitis. Bone marrow edema, erosions, joint effusion, and soft-tissue edema in the fingers most likely reflect pathology if present.