Sorafenib and continued erlotinib or sorafenib alone in patients with advanced non-small cell lung cancer progressing on erlotinib: A randomized phase II study of the Sarah Cannon Research Institute (SCRI)

•Single agent sorafenib and the combination of sorafenib plus erlotinib had limited activity in patients with refractory NSCLC.•Continuation of erlotinib post progression is unlikely to benefit NSCLC patients.•Both regimens used in the study were tolerable for patients. To evaluate the efficacy of e...

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Bibliographic Details
Published in:Lung cancer (Amsterdam, Netherlands) Netherlands), 2017-11, Vol.113, p.79-84
Main Authors: Spigel, David R., Rubin, Mark S., Gian, Victor G., Shipley, Dianna L., Burris, Howard A., Kosloff, Rebecca A., Shih, Kent C., Quinn, Raven, Greco, F. Anthony, Hainsworth, John D.
Format: Article
Language:English
Subjects:
EGFR
erlotinib
NSCLC
sorafenib
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Summary:•Single agent sorafenib and the combination of sorafenib plus erlotinib had limited activity in patients with refractory NSCLC.•Continuation of erlotinib post progression is unlikely to benefit NSCLC patients.•Both regimens used in the study were tolerable for patients. To evaluate the efficacy of erlotinib, continued after tumor progression, plus sorafenib versus sorafenib alone in patients with refractory metastatic non-small cell lung cancer (NSCLC) who previously benefitted from single-agent erlotinib. Patients with progressive refractory NSCLC who had previously benefitted from erlotinib (objective response or stable disease >8weeks) were randomized to receive treatment with either erlotinib and sorafenib (400mg orally twice daily) or sorafenib alone. Patients were evaluated for response every 8 weeks, and continued treatment until disease progression or intolerable toxicity. Fifty-three patients were randomized (erlotinib/sorafenib, 25; sorafenib, 28) and 52 patients received study treatment. Patients in both groups received a median of 8weeks of treatment. The median PFS was 3.1months for erlotinib/sorafenib versus 1.7months for sorafenib alone; response rates were 8% and 4%, respectively. Both regimens were tolerable, but toxicity was more frequent with erlotinib/sorafenib. These results do not suggest any benefit in continuing erlotinib after tumor progression in patients with refractory metastatic NSCLC. Both regimens tested had limited efficacy, consistent with results from other studies. ClinicalTrials.gov ID:NCT00609804
ISSN:0169-5002
1872-8332
DOI:10.1016/j.lungcan.2017.09.007