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Non‐alcoholic fatty liver disease and the development of reflux esophagitis: A cohort study
Background and Aim Non‐alcoholic fatty liver disease (NAFLD), a hepatic manifestation of the metabolic syndrome, is associated with gastroesophageal reflux disease in cross‐sectional studies, but a prospective association has not been evaluated. The current study aimed to determine whether NAFLD inc...
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| Published in: | Journal of gastroenterology and hepatology 2018-05, Vol.33 (5), p.1053-1058 |
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| Main Authors: | , , , , , , , , |
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| container_end_page | 1058 |
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| container_title | Journal of gastroenterology and hepatology |
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| creator | Min, Yang Won Kim, Youngha Gwak, Geum‐Youn Gu, Seonhye Kang, Danbee Cho, Soo Jin Guallar, Eliseo Cho, Juhee Sinn, Dong Hyun |
| description | Background and Aim
Non‐alcoholic fatty liver disease (NAFLD), a hepatic manifestation of the metabolic syndrome, is associated with gastroesophageal reflux disease in cross‐sectional studies, but a prospective association has not been evaluated. The current study aimed to determine whether NAFLD increases the risk of incident reflux esophagitis in a large cohort study.
Methods
We conducted a cohort study of 34 063 men and women without reflux esophagitis or other upper gastrointestinal disease at baseline who underwent health checkup examinations between January 2003 and December 2013. Fatty liver was diagnosed by ultrasound based on standard criteria. Reflux esophagitis was defined by the presence of at least grade A mucosal break on esophagogastroduodenoscopy.
Results
The prevalence of NAFLD at baseline was 33.2%. During 153 520.2 person‐years of follow‐up, the cumulative incidences of reflux esophagitis for participants without and with NAFLD were 9.6% and 13.8%, respectively (P |
| doi_str_mv | 10.1111/jgh.14042 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1963482955</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2025331932</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3532-51b5e2e35c9cc620c0170a9d5c5040d8b747b3613786b31bfc0aaa7e8f64ca3</originalsourceid><addsrcrecordid>eNp1kLtOwzAUQC0EoqUw8APIEgsMKX7mwVZVPIVggBVZjnPTpnLjEieFbnwC38iXYCgwIHEXL8dH9x6E9ikZ0jAns8l0SAURbAP1qRAkoomIN1GfpFRGGadZD-14PyOECJLIbdRjGeXhA-2jx1tXv7--aWvc1NnK4FK37QrbagkNLioP2gPWdYHbKeAClmDdYg51i12JGyht94LBu8VUT6q28qd4hD9FTYt92xWrXbRVauth7_sdoPvzs4fxZXRzd3E1Ht1EhkvOIklzCQy4NJkxMSOG0ITorJBGho2LNE9EkvOY8iSNc07z0hCtdQJpGQuj-QAdra2Lxj114Fs1r7wBa3UNrvOKZjEXKcukDOjhH3TmuqYOuylGmOShFWeBOl5TpnHehzPVoqnmulkpStRncRWKq6_igT34Nnb5HIpf8idxAE7WwHNlYfW_SV1fXK6VHw1Lip4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2025331932</pqid></control><display><type>article</type><title>Non‐alcoholic fatty liver disease and the development of reflux esophagitis: A cohort study</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>Min, Yang Won ; Kim, Youngha ; Gwak, Geum‐Youn ; Gu, Seonhye ; Kang, Danbee ; Cho, Soo Jin ; Guallar, Eliseo ; Cho, Juhee ; Sinn, Dong Hyun</creator><creatorcontrib>Min, Yang Won ; Kim, Youngha ; Gwak, Geum‐Youn ; Gu, Seonhye ; Kang, Danbee ; Cho, Soo Jin ; Guallar, Eliseo ; Cho, Juhee ; Sinn, Dong Hyun</creatorcontrib><description>Background and Aim
Non‐alcoholic fatty liver disease (NAFLD), a hepatic manifestation of the metabolic syndrome, is associated with gastroesophageal reflux disease in cross‐sectional studies, but a prospective association has not been evaluated. The current study aimed to determine whether NAFLD increases the risk of incident reflux esophagitis in a large cohort study.
Methods
We conducted a cohort study of 34 063 men and women without reflux esophagitis or other upper gastrointestinal disease at baseline who underwent health checkup examinations between January 2003 and December 2013. Fatty liver was diagnosed by ultrasound based on standard criteria. Reflux esophagitis was defined by the presence of at least grade A mucosal break on esophagogastroduodenoscopy.
Results
The prevalence of NAFLD at baseline was 33.2%. During 153 520.2 person‐years of follow‐up, the cumulative incidences of reflux esophagitis for participants without and with NAFLD were 9.6% and 13.8%, respectively (P < 0.001). The age‐adjusted and sex‐adjusted hazard ratio for the risk of reflux esophagitis development in participants with NAFLD compared with those without NAFLD was 1.15 (95% confidence interval 1.07–1.23; P < 0.001). However, this association disappeared after adjusting for body mass index and other metabolic factors (hazard ratio 1.01, 95% confidence interval 0.94–1.09; P = 0.79). Similarly, in multivariable‐adjusted models, there was no significant association between NAFLD severity and the risk of developing reflux esophagitis.
Conclusions
Non‐alcoholic fatty liver disease is not independently associated with the risk of the development of reflux esophagitis, but rather, reflux esophagitis is primarily the consequence of increased body mass index commonly associated with NAFLD.</description><identifier>ISSN: 0815-9319</identifier><identifier>EISSN: 1440-1746</identifier><identifier>DOI: 10.1111/jgh.14042</identifier><identifier>PMID: 29131401</identifier><language>eng</language><publisher>Australia: Wiley Subscription Services, Inc</publisher><subject>Body mass index ; Cohort analysis ; Confidence intervals ; erosive esophagitis ; Esophagitis ; Fatty liver ; Gastroesophageal reflux ; Health risk assessment ; Liver diseases ; Metabolic syndrome ; Metabolism ; Mucosa ; non‐alcoholic fatty liver disease ; Sex ratio ; Ultrasound</subject><ispartof>Journal of gastroenterology and hepatology, 2018-05, Vol.33 (5), p.1053-1058</ispartof><rights>2017 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd</rights><rights>2017 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.</rights><rights>2018 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3532-51b5e2e35c9cc620c0170a9d5c5040d8b747b3613786b31bfc0aaa7e8f64ca3</citedby><cites>FETCH-LOGICAL-c3532-51b5e2e35c9cc620c0170a9d5c5040d8b747b3613786b31bfc0aaa7e8f64ca3</cites><orcidid>0000-0002-7126-5554 ; 0000-0001-7471-1305</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29131401$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Min, Yang Won</creatorcontrib><creatorcontrib>Kim, Youngha</creatorcontrib><creatorcontrib>Gwak, Geum‐Youn</creatorcontrib><creatorcontrib>Gu, Seonhye</creatorcontrib><creatorcontrib>Kang, Danbee</creatorcontrib><creatorcontrib>Cho, Soo Jin</creatorcontrib><creatorcontrib>Guallar, Eliseo</creatorcontrib><creatorcontrib>Cho, Juhee</creatorcontrib><creatorcontrib>Sinn, Dong Hyun</creatorcontrib><title>Non‐alcoholic fatty liver disease and the development of reflux esophagitis: A cohort study</title><title>Journal of gastroenterology and hepatology</title><addtitle>J Gastroenterol Hepatol</addtitle><description>Background and Aim
Non‐alcoholic fatty liver disease (NAFLD), a hepatic manifestation of the metabolic syndrome, is associated with gastroesophageal reflux disease in cross‐sectional studies, but a prospective association has not been evaluated. The current study aimed to determine whether NAFLD increases the risk of incident reflux esophagitis in a large cohort study.
Methods
We conducted a cohort study of 34 063 men and women without reflux esophagitis or other upper gastrointestinal disease at baseline who underwent health checkup examinations between January 2003 and December 2013. Fatty liver was diagnosed by ultrasound based on standard criteria. Reflux esophagitis was defined by the presence of at least grade A mucosal break on esophagogastroduodenoscopy.
Results
The prevalence of NAFLD at baseline was 33.2%. During 153 520.2 person‐years of follow‐up, the cumulative incidences of reflux esophagitis for participants without and with NAFLD were 9.6% and 13.8%, respectively (P < 0.001). The age‐adjusted and sex‐adjusted hazard ratio for the risk of reflux esophagitis development in participants with NAFLD compared with those without NAFLD was 1.15 (95% confidence interval 1.07–1.23; P < 0.001). However, this association disappeared after adjusting for body mass index and other metabolic factors (hazard ratio 1.01, 95% confidence interval 0.94–1.09; P = 0.79). Similarly, in multivariable‐adjusted models, there was no significant association between NAFLD severity and the risk of developing reflux esophagitis.
Conclusions
Non‐alcoholic fatty liver disease is not independently associated with the risk of the development of reflux esophagitis, but rather, reflux esophagitis is primarily the consequence of increased body mass index commonly associated with NAFLD.</description><subject>Body mass index</subject><subject>Cohort analysis</subject><subject>Confidence intervals</subject><subject>erosive esophagitis</subject><subject>Esophagitis</subject><subject>Fatty liver</subject><subject>Gastroesophageal reflux</subject><subject>Health risk assessment</subject><subject>Liver diseases</subject><subject>Metabolic syndrome</subject><subject>Metabolism</subject><subject>Mucosa</subject><subject>non‐alcoholic fatty liver disease</subject><subject>Sex ratio</subject><subject>Ultrasound</subject><issn>0815-9319</issn><issn>1440-1746</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kLtOwzAUQC0EoqUw8APIEgsMKX7mwVZVPIVggBVZjnPTpnLjEieFbnwC38iXYCgwIHEXL8dH9x6E9ikZ0jAns8l0SAURbAP1qRAkoomIN1GfpFRGGadZD-14PyOECJLIbdRjGeXhA-2jx1tXv7--aWvc1NnK4FK37QrbagkNLioP2gPWdYHbKeAClmDdYg51i12JGyht94LBu8VUT6q28qd4hD9FTYt92xWrXbRVauth7_sdoPvzs4fxZXRzd3E1Ht1EhkvOIklzCQy4NJkxMSOG0ITorJBGho2LNE9EkvOY8iSNc07z0hCtdQJpGQuj-QAdra2Lxj114Fs1r7wBa3UNrvOKZjEXKcukDOjhH3TmuqYOuylGmOShFWeBOl5TpnHehzPVoqnmulkpStRncRWKq6_igT34Nnb5HIpf8idxAE7WwHNlYfW_SV1fXK6VHw1Lip4</recordid><startdate>201805</startdate><enddate>201805</enddate><creator>Min, Yang Won</creator><creator>Kim, Youngha</creator><creator>Gwak, Geum‐Youn</creator><creator>Gu, Seonhye</creator><creator>Kang, Danbee</creator><creator>Cho, Soo Jin</creator><creator>Guallar, Eliseo</creator><creator>Cho, Juhee</creator><creator>Sinn, Dong Hyun</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7126-5554</orcidid><orcidid>https://orcid.org/0000-0001-7471-1305</orcidid></search><sort><creationdate>201805</creationdate><title>Non‐alcoholic fatty liver disease and the development of reflux esophagitis: A cohort study</title><author>Min, Yang Won ; Kim, Youngha ; Gwak, Geum‐Youn ; Gu, Seonhye ; Kang, Danbee ; Cho, Soo Jin ; Guallar, Eliseo ; Cho, Juhee ; Sinn, Dong Hyun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3532-51b5e2e35c9cc620c0170a9d5c5040d8b747b3613786b31bfc0aaa7e8f64ca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Body mass index</topic><topic>Cohort analysis</topic><topic>Confidence intervals</topic><topic>erosive esophagitis</topic><topic>Esophagitis</topic><topic>Fatty liver</topic><topic>Gastroesophageal reflux</topic><topic>Health risk assessment</topic><topic>Liver diseases</topic><topic>Metabolic syndrome</topic><topic>Metabolism</topic><topic>Mucosa</topic><topic>non‐alcoholic fatty liver disease</topic><topic>Sex ratio</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Min, Yang Won</creatorcontrib><creatorcontrib>Kim, Youngha</creatorcontrib><creatorcontrib>Gwak, Geum‐Youn</creatorcontrib><creatorcontrib>Gu, Seonhye</creatorcontrib><creatorcontrib>Kang, Danbee</creatorcontrib><creatorcontrib>Cho, Soo Jin</creatorcontrib><creatorcontrib>Guallar, Eliseo</creatorcontrib><creatorcontrib>Cho, Juhee</creatorcontrib><creatorcontrib>Sinn, Dong Hyun</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of gastroenterology and hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Min, Yang Won</au><au>Kim, Youngha</au><au>Gwak, Geum‐Youn</au><au>Gu, Seonhye</au><au>Kang, Danbee</au><au>Cho, Soo Jin</au><au>Guallar, Eliseo</au><au>Cho, Juhee</au><au>Sinn, Dong Hyun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Non‐alcoholic fatty liver disease and the development of reflux esophagitis: A cohort study</atitle><jtitle>Journal of gastroenterology and hepatology</jtitle><addtitle>J Gastroenterol Hepatol</addtitle><date>2018-05</date><risdate>2018</risdate><volume>33</volume><issue>5</issue><spage>1053</spage><epage>1058</epage><pages>1053-1058</pages><issn>0815-9319</issn><eissn>1440-1746</eissn><abstract>Background and Aim
Non‐alcoholic fatty liver disease (NAFLD), a hepatic manifestation of the metabolic syndrome, is associated with gastroesophageal reflux disease in cross‐sectional studies, but a prospective association has not been evaluated. The current study aimed to determine whether NAFLD increases the risk of incident reflux esophagitis in a large cohort study.
Methods
We conducted a cohort study of 34 063 men and women without reflux esophagitis or other upper gastrointestinal disease at baseline who underwent health checkup examinations between January 2003 and December 2013. Fatty liver was diagnosed by ultrasound based on standard criteria. Reflux esophagitis was defined by the presence of at least grade A mucosal break on esophagogastroduodenoscopy.
Results
The prevalence of NAFLD at baseline was 33.2%. During 153 520.2 person‐years of follow‐up, the cumulative incidences of reflux esophagitis for participants without and with NAFLD were 9.6% and 13.8%, respectively (P < 0.001). The age‐adjusted and sex‐adjusted hazard ratio for the risk of reflux esophagitis development in participants with NAFLD compared with those without NAFLD was 1.15 (95% confidence interval 1.07–1.23; P < 0.001). However, this association disappeared after adjusting for body mass index and other metabolic factors (hazard ratio 1.01, 95% confidence interval 0.94–1.09; P = 0.79). Similarly, in multivariable‐adjusted models, there was no significant association between NAFLD severity and the risk of developing reflux esophagitis.
Conclusions
Non‐alcoholic fatty liver disease is not independently associated with the risk of the development of reflux esophagitis, but rather, reflux esophagitis is primarily the consequence of increased body mass index commonly associated with NAFLD.</abstract><cop>Australia</cop><pub>Wiley Subscription Services, Inc</pub><pmid>29131401</pmid><doi>10.1111/jgh.14042</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-7126-5554</orcidid><orcidid>https://orcid.org/0000-0001-7471-1305</orcidid></addata></record> |
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| ispartof | Journal of gastroenterology and hepatology, 2018-05, Vol.33 (5), p.1053-1058 |
| issn | 0815-9319 1440-1746 |
| language | eng |
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| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Body mass index Cohort analysis Confidence intervals erosive esophagitis Esophagitis Fatty liver Gastroesophageal reflux Health risk assessment Liver diseases Metabolic syndrome Metabolism Mucosa non‐alcoholic fatty liver disease Sex ratio Ultrasound |
| title | Non‐alcoholic fatty liver disease and the development of reflux esophagitis: A cohort study |
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