Vascular calcification is not related to serum fetuin-A and osteopontin levels in hemodialysis patients

• Published in: International urology and nephrology 2018, Vol.50 (1), p.137-142
• Main Authors: Ulutas, O., Taskapan, M. C., Dogan, A., Baysal, T., Taskapan, H.
• Format: Article
• Language: English
• Subjects: Age; Age Factors; Aged; alpha-2-HS-Glycoprotein - metabolism; Calcification; Calcification (ectopic); Calcium; Case-Control Studies; Diabetes Complications - complications; Diabetes mellitus; End-stage renal disease; Female; Hemodialysis; Humans; Kidney diseases; Kidney Failure, Chronic - blood; Kidney Failure, Chronic - complications; Kidney Failure, Chronic - therapy; Kidney transplantation; Male; Mammography; Medicine; Medicine & Public Health; Middle Aged; Nephrology; Nephrology - Original Paper; Osteopontin; Osteopontin - blood; Parathyroid; Parathyroid hormone; Parathyroid Hormone - blood; Patients; Radiography; Renal Dialysis; Risk Factors; Urology; Vascular Calcification - blood; Vascular Calcification - complications; Vascular Calcification - diagnostic imaging; Vitamin D; Vitamin D - analogs & derivatives; Vitamin D - blood
• ISSN: 0301-1623; 1573-2584
• DOI: 10.1007/s11255-017-1740-6

Introduction Vascular calcification (VC) in hemodialysis (HD) patients is a sign of severe cardiovascular disease and can predict cardiovascular outcomes. Fetuin-A and osteopontin (OPN) inhibit VC. Serum fetuin-A levels are lower in patients with end-stage kidney disease (ESKD) and in those who are on chronic HD therapy. However, there are limited data concerning OPN in patients who are on dialysis. The aim of our study was to determine VC in HD patients, the relationship between VC and 25-OH-vitamin D, fetuin-A, and OPN levels, and independent predictors of VC. Materials and methods Ninety-three patients with ESKD on HD therapy were recruited. Among these patients, 44 were male and 49 were female. The patient group was compared with a group of 20 healthy controls of similar age and sex. A plain radiograph of the hand was taken using a mammography machine for the evaluation of VC. Serum fetuin-A, OPN, and 25-OH-vitamin D levels of both patients and controls were measured. Results VC was detected in 45 (48.4%) HD patients. When patients were compared with healthy controls, fetuin-A levels ( p