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Vascular calcification is not related to serum fetuin-A and osteopontin levels in hemodialysis patients
Introduction Vascular calcification (VC) in hemodialysis (HD) patients is a sign of severe cardiovascular disease and can predict cardiovascular outcomes. Fetuin-A and osteopontin (OPN) inhibit VC. Serum fetuin-A levels are lower in patients with end-stage kidney disease (ESKD) and in those who are...
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| Published in: | International urology and nephrology 2018, Vol.50 (1), p.137-142 |
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| creator | Ulutas, O. Taskapan, M. C. Dogan, A. Baysal, T. Taskapan, H. |
| description | Introduction
Vascular calcification (VC) in hemodialysis (HD) patients is a sign of severe cardiovascular disease and can predict cardiovascular outcomes. Fetuin-A and osteopontin (OPN) inhibit VC. Serum fetuin-A levels are lower in patients with end-stage kidney disease (ESKD) and in those who are on chronic HD therapy. However, there are limited data concerning OPN in patients who are on dialysis. The aim of our study was to determine VC in HD patients, the relationship between VC and 25-OH-vitamin D, fetuin-A, and OPN levels, and independent predictors of VC.
Materials and methods
Ninety-three patients with ESKD on HD therapy were recruited. Among these patients, 44 were male and 49 were female. The patient group was compared with a group of 20 healthy controls of similar age and sex. A plain radiograph of the hand was taken using a mammography machine for the evaluation of VC. Serum fetuin-A, OPN, and 25-OH-vitamin D levels of both patients and controls were measured.
Results
VC was detected in 45 (48.4%) HD patients. When patients were compared with healthy controls, fetuin-A levels (
p
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| doi_str_mv | 10.1007/s11255-017-1740-6 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1964272907</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1964272907</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-2c154d48d23d16aec5fce4076e47afad4a63ab7fee14e3e286d6e58dfab6b8fb3</originalsourceid><addsrcrecordid>eNp1kU1rVTEQhoMo9rb6A9xIwI2baL5Ocu6ylGqFght1G3KSSU3JSa5JjtB_by63igiuMpBnnhnmRegVo-8Ypfp9Y4xPE6FME6YlJeoJ2rFJC8KnWT5FOyooI0xxcYbOW7unlO5nSp-jM75nQiqmd-jum21uS7ZiZ5OLITrbY8k4NpxLxxWS7eBxL7hB3VYcoG8xk0tss8eldSiHknvMOMFPSA2P6jusxUebHtqQHIYOcm8v0LNgU4OXj-8F-vrh-svVDbn9_PHT1eUtcULzTrhjk_Ry9lx4piy4KTiQVCuQ2gbrpVXCLjoAMAkC-Ky8gmn2wS5qmcMiLtDbk_dQy48NWjdrbA5SshnK1gzbK8k131M90Df_oPdlq3lsd6TEuJ2c-aDYiXK1tFYhmEONq60PhlFzTMGcUjAjBXNMwajR8_rRvC0r-D8dv88-AH4C2vjKd1D_Gv1f6y_MdJQg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1963301482</pqid></control><display><type>article</type><title>Vascular calcification is not related to serum fetuin-A and osteopontin levels in hemodialysis patients</title><source>Springer Nature</source><creator>Ulutas, O. ; Taskapan, M. C. ; Dogan, A. ; Baysal, T. ; Taskapan, H.</creator><creatorcontrib>Ulutas, O. ; Taskapan, M. C. ; Dogan, A. ; Baysal, T. ; Taskapan, H.</creatorcontrib><description>Introduction
Vascular calcification (VC) in hemodialysis (HD) patients is a sign of severe cardiovascular disease and can predict cardiovascular outcomes. Fetuin-A and osteopontin (OPN) inhibit VC. Serum fetuin-A levels are lower in patients with end-stage kidney disease (ESKD) and in those who are on chronic HD therapy. However, there are limited data concerning OPN in patients who are on dialysis. The aim of our study was to determine VC in HD patients, the relationship between VC and 25-OH-vitamin D, fetuin-A, and OPN levels, and independent predictors of VC.
Materials and methods
Ninety-three patients with ESKD on HD therapy were recruited. Among these patients, 44 were male and 49 were female. The patient group was compared with a group of 20 healthy controls of similar age and sex. A plain radiograph of the hand was taken using a mammography machine for the evaluation of VC. Serum fetuin-A, OPN, and 25-OH-vitamin D levels of both patients and controls were measured.
Results
VC was detected in 45 (48.4%) HD patients. When patients were compared with healthy controls, fetuin-A levels (
p
< 0.029) were significantly lower in patients, whereas OPN (
p
< 0.000) and VC (
p
< 0.002) were significantly higher in the patient group. Age [odds ratio (OR) 1.036], the presence of diabetes mellitus (DM) (OR 17.527), and high parathyroid hormone (PTH) levels (OR 1.002) were independent predictors of VC in a logistic regression model including the following factors: age, the presence of DM, HD duration, and serum albumin, phosphate, PTH, 25-OH-vitamin D, fetuin-A, OPN, and calcium levels. No significant correlation was found between patients with VC and patients without VC in terms of fetuin-A, OPN, and 25-OH-vitamin D levels.
Conclusions
VC is a frequent sign in patients undergoing HD and is not related to serum fetuin-A and osteopontin levels. Age, the presence of DM, and high PTH levels were independent predictors of VC in patients undergoing HD. Further studies are warranted to understand the mechanism underlying and the factors contributing to VC.</description><identifier>ISSN: 0301-1623</identifier><identifier>EISSN: 1573-2584</identifier><identifier>DOI: 10.1007/s11255-017-1740-6</identifier><identifier>PMID: 29134617</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Age ; Age Factors ; Aged ; alpha-2-HS-Glycoprotein - metabolism ; Calcification ; Calcification (ectopic) ; Calcium ; Case-Control Studies ; Diabetes Complications - complications ; Diabetes mellitus ; End-stage renal disease ; Female ; Hemodialysis ; Humans ; Kidney diseases ; Kidney Failure, Chronic - blood ; Kidney Failure, Chronic - complications ; Kidney Failure, Chronic - therapy ; Kidney transplantation ; Male ; Mammography ; Medicine ; Medicine & Public Health ; Middle Aged ; Nephrology ; Nephrology - Original Paper ; Osteopontin ; Osteopontin - blood ; Parathyroid ; Parathyroid hormone ; Parathyroid Hormone - blood ; Patients ; Radiography ; Renal Dialysis ; Risk Factors ; Urology ; Vascular Calcification - blood ; Vascular Calcification - complications ; Vascular Calcification - diagnostic imaging ; Vitamin D ; Vitamin D - analogs & derivatives ; Vitamin D - blood</subject><ispartof>International urology and nephrology, 2018, Vol.50 (1), p.137-142</ispartof><rights>Springer Science+Business Media B.V., part of Springer Nature 2017</rights><rights>International Urology and Nephrology is a copyright of Springer, (2017). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-2c154d48d23d16aec5fce4076e47afad4a63ab7fee14e3e286d6e58dfab6b8fb3</citedby><cites>FETCH-LOGICAL-c372t-2c154d48d23d16aec5fce4076e47afad4a63ab7fee14e3e286d6e58dfab6b8fb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29134617$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ulutas, O.</creatorcontrib><creatorcontrib>Taskapan, M. C.</creatorcontrib><creatorcontrib>Dogan, A.</creatorcontrib><creatorcontrib>Baysal, T.</creatorcontrib><creatorcontrib>Taskapan, H.</creatorcontrib><title>Vascular calcification is not related to serum fetuin-A and osteopontin levels in hemodialysis patients</title><title>International urology and nephrology</title><addtitle>Int Urol Nephrol</addtitle><addtitle>Int Urol Nephrol</addtitle><description>Introduction
Vascular calcification (VC) in hemodialysis (HD) patients is a sign of severe cardiovascular disease and can predict cardiovascular outcomes. Fetuin-A and osteopontin (OPN) inhibit VC. Serum fetuin-A levels are lower in patients with end-stage kidney disease (ESKD) and in those who are on chronic HD therapy. However, there are limited data concerning OPN in patients who are on dialysis. The aim of our study was to determine VC in HD patients, the relationship between VC and 25-OH-vitamin D, fetuin-A, and OPN levels, and independent predictors of VC.
Materials and methods
Ninety-three patients with ESKD on HD therapy were recruited. Among these patients, 44 were male and 49 were female. The patient group was compared with a group of 20 healthy controls of similar age and sex. A plain radiograph of the hand was taken using a mammography machine for the evaluation of VC. Serum fetuin-A, OPN, and 25-OH-vitamin D levels of both patients and controls were measured.
Results
VC was detected in 45 (48.4%) HD patients. When patients were compared with healthy controls, fetuin-A levels (
p
< 0.029) were significantly lower in patients, whereas OPN (
p
< 0.000) and VC (
p
< 0.002) were significantly higher in the patient group. Age [odds ratio (OR) 1.036], the presence of diabetes mellitus (DM) (OR 17.527), and high parathyroid hormone (PTH) levels (OR 1.002) were independent predictors of VC in a logistic regression model including the following factors: age, the presence of DM, HD duration, and serum albumin, phosphate, PTH, 25-OH-vitamin D, fetuin-A, OPN, and calcium levels. No significant correlation was found between patients with VC and patients without VC in terms of fetuin-A, OPN, and 25-OH-vitamin D levels.
Conclusions
VC is a frequent sign in patients undergoing HD and is not related to serum fetuin-A and osteopontin levels. Age, the presence of DM, and high PTH levels were independent predictors of VC in patients undergoing HD. Further studies are warranted to understand the mechanism underlying and the factors contributing to VC.</description><subject>Age</subject><subject>Age Factors</subject><subject>Aged</subject><subject>alpha-2-HS-Glycoprotein - metabolism</subject><subject>Calcification</subject><subject>Calcification (ectopic)</subject><subject>Calcium</subject><subject>Case-Control Studies</subject><subject>Diabetes Complications - complications</subject><subject>Diabetes mellitus</subject><subject>End-stage renal disease</subject><subject>Female</subject><subject>Hemodialysis</subject><subject>Humans</subject><subject>Kidney diseases</subject><subject>Kidney Failure, Chronic - blood</subject><subject>Kidney Failure, Chronic - complications</subject><subject>Kidney Failure, Chronic - therapy</subject><subject>Kidney transplantation</subject><subject>Male</subject><subject>Mammography</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Nephrology</subject><subject>Nephrology - Original Paper</subject><subject>Osteopontin</subject><subject>Osteopontin - blood</subject><subject>Parathyroid</subject><subject>Parathyroid hormone</subject><subject>Parathyroid Hormone - blood</subject><subject>Patients</subject><subject>Radiography</subject><subject>Renal Dialysis</subject><subject>Risk Factors</subject><subject>Urology</subject><subject>Vascular Calcification - blood</subject><subject>Vascular Calcification - complications</subject><subject>Vascular Calcification - diagnostic imaging</subject><subject>Vitamin D</subject><subject>Vitamin D - analogs & derivatives</subject><subject>Vitamin D - blood</subject><issn>0301-1623</issn><issn>1573-2584</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kU1rVTEQhoMo9rb6A9xIwI2baL5Ocu6ylGqFght1G3KSSU3JSa5JjtB_by63igiuMpBnnhnmRegVo-8Ypfp9Y4xPE6FME6YlJeoJ2rFJC8KnWT5FOyooI0xxcYbOW7unlO5nSp-jM75nQiqmd-jum21uS7ZiZ5OLITrbY8k4NpxLxxWS7eBxL7hB3VYcoG8xk0tss8eldSiHknvMOMFPSA2P6jusxUebHtqQHIYOcm8v0LNgU4OXj-8F-vrh-svVDbn9_PHT1eUtcULzTrhjk_Ry9lx4piy4KTiQVCuQ2gbrpVXCLjoAMAkC-Ky8gmn2wS5qmcMiLtDbk_dQy48NWjdrbA5SshnK1gzbK8k131M90Df_oPdlq3lsd6TEuJ2c-aDYiXK1tFYhmEONq60PhlFzTMGcUjAjBXNMwajR8_rRvC0r-D8dv88-AH4C2vjKd1D_Gv1f6y_MdJQg</recordid><startdate>2018</startdate><enddate>2018</enddate><creator>Ulutas, O.</creator><creator>Taskapan, M. C.</creator><creator>Dogan, A.</creator><creator>Baysal, T.</creator><creator>Taskapan, H.</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>2018</creationdate><title>Vascular calcification is not related to serum fetuin-A and osteopontin levels in hemodialysis patients</title><author>Ulutas, O. ; Taskapan, M. C. ; Dogan, A. ; Baysal, T. ; Taskapan, H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-2c154d48d23d16aec5fce4076e47afad4a63ab7fee14e3e286d6e58dfab6b8fb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Age</topic><topic>Age Factors</topic><topic>Aged</topic><topic>alpha-2-HS-Glycoprotein - metabolism</topic><topic>Calcification</topic><topic>Calcification (ectopic)</topic><topic>Calcium</topic><topic>Case-Control Studies</topic><topic>Diabetes Complications - complications</topic><topic>Diabetes mellitus</topic><topic>End-stage renal disease</topic><topic>Female</topic><topic>Hemodialysis</topic><topic>Humans</topic><topic>Kidney diseases</topic><topic>Kidney Failure, Chronic - blood</topic><topic>Kidney Failure, Chronic - complications</topic><topic>Kidney Failure, Chronic - therapy</topic><topic>Kidney transplantation</topic><topic>Male</topic><topic>Mammography</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Nephrology</topic><topic>Nephrology - Original Paper</topic><topic>Osteopontin</topic><topic>Osteopontin - blood</topic><topic>Parathyroid</topic><topic>Parathyroid hormone</topic><topic>Parathyroid Hormone - blood</topic><topic>Patients</topic><topic>Radiography</topic><topic>Renal Dialysis</topic><topic>Risk Factors</topic><topic>Urology</topic><topic>Vascular Calcification - blood</topic><topic>Vascular Calcification - complications</topic><topic>Vascular Calcification - diagnostic imaging</topic><topic>Vitamin D</topic><topic>Vitamin D - analogs & derivatives</topic><topic>Vitamin D - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ulutas, O.</creatorcontrib><creatorcontrib>Taskapan, M. C.</creatorcontrib><creatorcontrib>Dogan, A.</creatorcontrib><creatorcontrib>Baysal, T.</creatorcontrib><creatorcontrib>Taskapan, H.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>International urology and nephrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ulutas, O.</au><au>Taskapan, M. C.</au><au>Dogan, A.</au><au>Baysal, T.</au><au>Taskapan, H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vascular calcification is not related to serum fetuin-A and osteopontin levels in hemodialysis patients</atitle><jtitle>International urology and nephrology</jtitle><stitle>Int Urol Nephrol</stitle><addtitle>Int Urol Nephrol</addtitle><date>2018</date><risdate>2018</risdate><volume>50</volume><issue>1</issue><spage>137</spage><epage>142</epage><pages>137-142</pages><issn>0301-1623</issn><eissn>1573-2584</eissn><abstract>Introduction
Vascular calcification (VC) in hemodialysis (HD) patients is a sign of severe cardiovascular disease and can predict cardiovascular outcomes. Fetuin-A and osteopontin (OPN) inhibit VC. Serum fetuin-A levels are lower in patients with end-stage kidney disease (ESKD) and in those who are on chronic HD therapy. However, there are limited data concerning OPN in patients who are on dialysis. The aim of our study was to determine VC in HD patients, the relationship between VC and 25-OH-vitamin D, fetuin-A, and OPN levels, and independent predictors of VC.
Materials and methods
Ninety-three patients with ESKD on HD therapy were recruited. Among these patients, 44 were male and 49 were female. The patient group was compared with a group of 20 healthy controls of similar age and sex. A plain radiograph of the hand was taken using a mammography machine for the evaluation of VC. Serum fetuin-A, OPN, and 25-OH-vitamin D levels of both patients and controls were measured.
Results
VC was detected in 45 (48.4%) HD patients. When patients were compared with healthy controls, fetuin-A levels (
p
< 0.029) were significantly lower in patients, whereas OPN (
p
< 0.000) and VC (
p
< 0.002) were significantly higher in the patient group. Age [odds ratio (OR) 1.036], the presence of diabetes mellitus (DM) (OR 17.527), and high parathyroid hormone (PTH) levels (OR 1.002) were independent predictors of VC in a logistic regression model including the following factors: age, the presence of DM, HD duration, and serum albumin, phosphate, PTH, 25-OH-vitamin D, fetuin-A, OPN, and calcium levels. No significant correlation was found between patients with VC and patients without VC in terms of fetuin-A, OPN, and 25-OH-vitamin D levels.
Conclusions
VC is a frequent sign in patients undergoing HD and is not related to serum fetuin-A and osteopontin levels. Age, the presence of DM, and high PTH levels were independent predictors of VC in patients undergoing HD. Further studies are warranted to understand the mechanism underlying and the factors contributing to VC.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>29134617</pmid><doi>10.1007/s11255-017-1740-6</doi><tpages>6</tpages></addata></record> |
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| source | Springer Nature |
| subjects | Age Age Factors Aged alpha-2-HS-Glycoprotein - metabolism Calcification Calcification (ectopic) Calcium Case-Control Studies Diabetes Complications - complications Diabetes mellitus End-stage renal disease Female Hemodialysis Humans Kidney diseases Kidney Failure, Chronic - blood Kidney Failure, Chronic - complications Kidney Failure, Chronic - therapy Kidney transplantation Male Mammography Medicine Medicine & Public Health Middle Aged Nephrology Nephrology - Original Paper Osteopontin Osteopontin - blood Parathyroid Parathyroid hormone Parathyroid Hormone - blood Patients Radiography Renal Dialysis Risk Factors Urology Vascular Calcification - blood Vascular Calcification - complications Vascular Calcification - diagnostic imaging Vitamin D Vitamin D - analogs & derivatives Vitamin D - blood |
| title | Vascular calcification is not related to serum fetuin-A and osteopontin levels in hemodialysis patients |
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