National Institute of Allergy and Infectious Diseases workshop report: “Chlamydia vaccines: The way forward”

Chlamydia trachomatis (Ct), an intracellular pathogen, is the most common bacterial sexually transmitted infection. In addition to acute cervicitis and urethritis, Ct can lead to serious sequelae of significant public health burden including pelvic inflammatory disease (PID) and infertility. Ct cont...

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Bibliographic Details
Published in:Vaccine 2019-11, Vol.37 (50), p.7346-7354
Main Authors: Zhong, Guangming, Brunham, Robert C., de la Maza, Luis M., Darville, Toni, Deal, Carolyn
Format: Article
Language:English
Subjects:
Allergies
Animal models
Antigens
Bacteria
Cervicitis
Chlamydia
Chlamydia trachomatis
Chlamydia vaccine
Clinical trials
Complications
Cost analysis
Disease control
Human papillomavirus
Infections
Infectious diseases
Infertility
Inflammatory diseases
NMR
Nuclear magnetic resonance
Pathology
Pelvic inflammatory disease
Proportional integral derivative
Proteins
Public health
Questions
R&D
Research & development
Sexually transmitted diseases
STD
Urethritis
Vaccine development
Vaccines
Womens health
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Summary:Chlamydia trachomatis (Ct), an intracellular pathogen, is the most common bacterial sexually transmitted infection. In addition to acute cervicitis and urethritis, Ct can lead to serious sequelae of significant public health burden including pelvic inflammatory disease (PID) and infertility. Ct control efforts have not resulted in desired outcomes such as reduced incidence and reinfection, and this highlights the need for the development of an effective Ct vaccine. To this end, NIAID organized a workshop to consider the current status of Ct vaccine research and address critical questions in Ct vaccine design and clinical testing. Topics included the goal(s) of a vaccine and the feasibility of achieving these goals, animal models of infection including mouse and nonhuman primate (NHP) models, and correlates of protection to guide vaccine design. Decades of research have provided both whole cell-based and subunit vaccine candidates for development. At least one is currently in clinical development and efforts now need to be directed toward further development of the most attractive candidates. Overall, the discussions and presentations from the workshop highlighted optimism about the current status of Ct vaccine research and detailed the remaining gaps and questions needed to move vaccines forward.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2017.10.075