Surface modification of electrospun poly-(l-lactic) acid scaffolds by reactive magnetron sputtering

• Published in: Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2018-02, Vol.162, p.43-51
• Main Authors: Bolbasov, E.N., Maryin, P.V., Stankevich, K.S., Kozelskaya, A.I., Shesterikov, E.V., Khodyrevskaya, Yu. I., Nasonova, M.V., Shishkova, D.K., Kudryavtseva, Yu. A., Anissimov, Y.G., Tverdokhlebov, S.I.
• Format: Article
• Language: English
• Subjects: Biocompatibility; Electrospun PLLA scaffold; Reactive magnetron sputtering
• ISSN: 0927-7765; 1873-4367
• DOI: 10.1016/j.colsurfb.2017.11.028

[Display omitted] •Electrospun PLLA scaffold modification by titanium target magnetron sputtering.•Coating does not change physicomechanical properties of electrospun PLLA scaffolds.•Modification improves the surface hydrophilicity of PLLA scaffolds.•Modification enhances the biocompatibility of PLLA scaffolds in vivo.•Rate of scaffold replacement in vivo depends on the plasma treatment time. In this study, we modified the surface of bioresorbable electrospun poly-(l-lactic) acid (PLLA) scaffolds by reactive magnetron sputtering of a titanium target under a nitrogen atmosphere. We examined the influence of the plasma treatment time on the structure and properties of electrospun PLLA scaffolds using SEM, XRF, FTIR, XRD, optical goniometry, and mechanical testing. It was observed that the coating formed did not change physicomechanical properties of electrospun PLLA scaffolds and simultaneously, increased their hydrophilicity. No adverse tissue reaction up to 3 months after subcutaneous implantation of the modified scaffolds was detected in in-vivo rat model. The rate of scaffold replacement by the recipient tissue in-vivo was observed to depend on the plasma treatment time.