Being Born Too Small and Too Early May Alter Sleep in Childhood

Fetal growth restriction (FGR) occurs in up to 10% of pregnancies and is associated with increased risk of prematurity and neurodevelopmental impairment. FGR also alters sleep state distribution in utero and maturation in infancy. Currently, limited data on the long-term associations of FGR and chil...

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Bibliographic Details
Published in:Sleep (New York, N.Y.) N.Y.), 2018-02, Vol.41 (2)
Main Authors: Yiallourou, Stephanie R, Arena, Bianca C, Wallace, Euan M, Odoi, Alexsandria, Hollis, Samantha, Weichard, Aidan, Horne, Rosemary S C
Format: Article
Language:English
Subjects:
Childhood
Sleep
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Summary:Fetal growth restriction (FGR) occurs in up to 10% of pregnancies and is associated with increased risk of prematurity and neurodevelopmental impairment. FGR also alters sleep state distribution in utero and maturation in infancy. Currently, limited data on the long-term associations of FGR and childhood sleep exist. Accordingly, we assessed the associations between preterm birth and FGR and sleep in children aged 5-12 years. 17 children born preterm and FGR, 15 children born preterm but appropriately grown (AGA) and 20 term AGA children (controls) were studied using overnight polysomnography. Sleep macro-architecture was assessed using standard criteria and sleep micro-architecture was assessed using spectral analysis of the EEG (C4-M1) with Total, Delta (0.5Hz-3.9Hz), Theta (4.0Hz-7.9Hz), Alpha (8.0Hz-11.9Hz), Sigma (12.0Hz-13.9Hz) and Beta Power (14.0Hz-30Hz) calculated. For sleep macro-architecture, preterm FGR children had higher N2% compared to term AGA children (p
ISSN:0161-8105
1550-9109
DOI:10.1093/sleep/zsx193