Genetics, environment, and asthma associated with celiac disease in the extended family of an affected child

Celiac disease (CD) is an autoimmune enteropathy associated with gluten ingestion. In extended families of celiac patients that live in close proximity of one another, shared genetic and environmental factors can predispose them to CD. The aim of this study was to provide evidence about the genetic...

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Bibliographic Details
Published in:Revista de Gastroenterología de México (English Edition) 2018-04, Vol.83 (2), p.79-85
Main Authors: Sigala-Robles, R, Aguayo-Patrón, S V, Calderón de la Barca, A M
Format: Article
Language:eng ; spa
Subjects:
Adult
Asthma - complications
Asthma - genetics
Celiac Disease - diagnosis
Celiac Disease - etiology
Child
Environment
Family
Female
Genetic Markers
Genetic Predisposition to Disease
Haplotypes
HLA-DQ Antigens - genetics
Humans
Male
Middle Aged
Risk Factors
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Summary:Celiac disease (CD) is an autoimmune enteropathy associated with gluten ingestion. In extended families of celiac patients that live in close proximity of one another, shared genetic and environmental factors can predispose them to CD. The aim of this study was to provide evidence about the genetic and environmental factors involved in the development of CD in the extended family of a pediatric patient. The medical history, environmental conditions, and participant weight, height, and peripheral blood samples were evaluated. The HLA-DQ2/DQ8 haplotypes were genotyped through qPCR testing and the IgA anti-gliadin and anti-transglutaminase antibodies were quantified using the ELISA test. Twelve close-living maternal relatives of the index case participated in the study. Eight of them presented with the HLA-DQ2 haplotype, inherited from the grandfather, and 7/12 and 9/12 were positive for IgA anti-gliadin and IgA anti-transglutaminase antibodies, respectively. The main intestinal symptoms stated by the participants were abdominal bloating, excess flatulence, constipation, and gastroesophageal reflux. The most frequent extra-intestinal symptoms were fatigue, stress, and anxiety. In addition, 6/13 participants had bronchial asthma. The extended family living in close proximity of one another shared a genetic predisposition, environmental conditions, and asthma, which could have predisposed them to celiac disease.
ISSN:0375-0906
2255-534X
DOI:10.1016/j.rgmx.2017.05.006