Schistosomiasis in the first 1000 days

Infections during the first 1000 days—the period from conception to a child's second birthday—can have lifelong effects on health, because this is a crucial phase of growth and development. There is increasing recognition of the burden and potential effects of schistosomiasis in women of reprod...

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Bibliographic Details
Published in:The Lancet infectious diseases 2018-06, Vol.18 (6), p.e193-e203
Main Authors: Freer, Joseph B, Bourke, Claire D, Durhuus, Gunn H, Kjetland, Eyrun F, Prendergast, Andrew J
Format: Article
Language:English
Subjects:
Adolescents
Adult
Age
Anthelmintics - administration & dosage
Anthelmintics - therapeutic use
Child abuse & neglect
Child development
Child, Preschool
Children
Children & youth
Communicable diseases
Councils
Disease transmission
Epidemiology
Female
Grants
Health Policy
Health promotion
HIV
Human immunodeficiency virus
Humans
Infant
Infant, Newborn
Infections
Infectious Disease Transmission, Vertical
Infectious diseases
Mass Drug Administration
Medical colleges
Microscopy
Mortality
Mothers
Pregnancy
Public health
Schistosoma haematobium
Schistosoma japonicum
Schistosoma mansoni
Schistosomiasis
Schistosomiasis - parasitology
Schistosomiasis - pathology
Schistosomiasis - transmission
Tropical diseases
Urine
Womens health
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Summary:Infections during the first 1000 days—the period from conception to a child's second birthday—can have lifelong effects on health, because this is a crucial phase of growth and development. There is increasing recognition of the burden and potential effects of schistosomiasis in women of reproductive age and young children. Exposure to schistosomes during pregnancy can modulate infant immune development and schistosomiasis can occur from early infancy, such that the high disease burden found in adolescents is often due to accumulation of infections with long-lived schistosomes from early life. Women of reproductive age and young children are largely neglected in mass drug administration programmes, but early treatment could avert subsequent disease. We evaluate the evidence that early schistosomiasis has adverse effects on birth, growth, and development. We also discuss the case for expanding public health interventions for schistosomiasis in women of reproductive age and preschool-age children, and the need for further research to evaluate the potential of treating women pre-conception to maximise health across the life course.
ISSN:1473-3099
1474-4457
DOI:10.1016/S1473-3099(17)30490-5