Amino acids/peptides conjugated heterocycles: A tool for the recent development of novel therapeutic agents

[Display omitted] Amino acids/peptide conjugated heterocycles represent an important class of therapeutical agents. Biologically active heterocycles are conjugated with amino acids or peptides to increase the drug resistance. Furthermore, the amino acid/peptide based drugs have low toxicity, ample b...

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Bibliographic Details
Published in:Bioorganic chemistry 2018-02, Vol.76, p.113-129
Main Authors: Wang, Meng, Rakesh, K.P., Leng, Jing, Fang, Wan-Yin, Ravindar, L., Channe Gowda, D., Qin, Hua-Li
Format: Article
Language:English
Subjects:
Amino acids
Amino Acids - chemistry
Amino Acids - pharmacology
Animals
Anti-Infective Agents - chemistry
Antineoplastic Agents - chemistry
Biological activities
Conjugation
Heterocycles
Humans
Peptides
Peptides - chemistry
Peptides - pharmacology
SAR
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Summary:[Display omitted] Amino acids/peptide conjugated heterocycles represent an important class of therapeutical agents. Biologically active heterocycles are conjugated with amino acids or peptides to increase the drug resistance. Furthermore, the amino acid/peptide based drugs have low toxicity, ample bioavailability and permeability, modest potency and good metabolic and pharmacokinetic properties. Synthetic amino acid/peptides based heterocyclic conjugates constitute a promising choice for the development of new, less toxic and safer conventional pharmaceutical drugs in the near future. In this review, we discuss and highlight the recent findings of the structural features that encourage biological applications of amino acid/peptides based conjugates.
ISSN:0045-2068
1090-2120
DOI:10.1016/j.bioorg.2017.11.007