Pregnancy Protection Program in a Large Chemical Company: Infant Outcomes

Objectives: The purpose of this study was to investigate reproductive outcomes in infants relative to maternal exposures in the chemical industry. Methods: Via questionnaires administered after the pregnancy announcement, end of pregnancy, and 1 year later, infant outcomes were documented far 1147 l...

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Bibliographic Details
Published in:Journal of occupational and environmental medicine 2007-05, Vol.49 (5), p.519-525
Main Authors: Frey, Gunild M., Ott, M. Gerald, Messerer, Peter, Nasterlack, Michael, Zober, Andreas, Queißer-Luft, Annette
Format: Article
Language:English
Subjects:
Adolescent
Adult
Babies
Biological and medical sciences
Chemical Industry
Clinical outcomes
Data Collection
Diseases of mother, fetus and pregnancy
Embryology: invertebrates and vertebrates. Teratology
Female
Fundamental and applied biological sciences. Psychology
Germany
Gynecology. Andrology. Obstetrics
Hazardous materials
Hazardous Substances
Health hazards
Human exposure
Humans
Infant, Newborn
Male
Medical sciences
Occupational Exposure - prevention & control
Occupational safety
ORIGINAL ARTICLES
Pregnancy
Pregnancy Outcome
Pregnancy. Fetus. Placenta
Teratology. Teratogens
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Summary:Objectives: The purpose of this study was to investigate reproductive outcomes in infants relative to maternal exposures in the chemical industry. Methods: Via questionnaires administered after the pregnancy announcement, end of pregnancy, and 1 year later, infant outcomes were documented far 1147 live births. Maternal exposure factors were evaluated relative to birth height and weight, sex ratio, Apgar score at 5 minutes, and major malformations. Results: Birth height and weight, sex ratio, and Apgar score did not differ by maternal work area or chemical hazard categories. Major malformations (3.1%) and organspecific anomalies were consistent with the experience of a regional bir defects registry. Rates of malformation were marginally higher in infan born to women assigned to chemical versus office jobs. Conclusions: Infant outcomes to date have been consistent with comparable finding from population-based studies. Longer-term observation will be needed assess trends for low-frequency outcomes and more specific materna exposures.
ISSN:1076-2752
1536-5948
DOI:10.1097/JOM.0b013e31804630ea