Suckling in litters with different sizes, and early and late swimming exercise differentially modulates anxiety-like behavior, memory and electrocorticogram potentiation after spreading depression in rats

Objective: Analyze the hypothesis that swimming exercise, in rats suckled under distinct litter sizes, alters behavioral parameters suggestive of anxiety and recognition memory, and the electrocorticogram potentiation that occurs after the excitability-related phenomenon that is known as cortical sp...

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Bibliographic Details
Published in:Nutritional neuroscience 2019-07, Vol.22 (7), p.464-473
Main Authors: e Silva-Gondim, Mariana Barros, de Souza, Thays Kallyne Marinho, Rodrigues, Marcelo Cairrão Araújo, Guedes, Rubem Carlos Araújo
Format: Article
Language:English
Subjects:
Animals
Animals, Suckling
Anxiety
Behavior, Animal
Body Weight
Brain - physiology
Brain development
Brain excitability
Cortical Spreading Depression
Electrocorticography
Electroencephalogram
Female
Lactation
Litter Size
Male
Nutritional deficiency
Nutritional Status
Organ Size
Rat
Rats, Wistar
Recognition (Psychology)
Swimming
Swimming exercise
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Summary:Objective: Analyze the hypothesis that swimming exercise, in rats suckled under distinct litter sizes, alters behavioral parameters suggestive of anxiety and recognition memory, and the electrocorticogram potentiation that occurs after the excitability-related phenomenon that is known as cortical spreading depression (CSD). Methods: Male Wistar rats were suckled in litters with six or 12 pups (L 6 and L 12 groups). Animals swam at postnatal days (P) 8-23, or P60-P75 (early-exercised or late-exercised groups, respectively), or remained no-exercised. Behavioral tests (open field - OF and object recognition - OR) were conducted between P77 and P80. Between P90 and P120, ECoG was recorded for 2 hours. After this 'baseline' recording, CSD was elicited every 30 minutes over the course of 2 hours. Results: Early swimming enhanced the number of entries and the percentage of time in the OF-center (P 
ISSN:1028-415X
1476-8305
DOI:10.1080/1028415X.2017.1407472