Hyponatremia in patients receiving parenteral nutrition: the importance of correcting serum sodium for total proteins. The role of the composition of parenteral nutrition in the development of hyponatremia

Background/objectives Hyponatremia is the most common electrolyte disorder, and is associated with high-morbimortality rates. The true prevalence of hyponatremia in patients on parenteral nutrition (PN) is unknown, and the relationship between PN composition and development of hyponatremia has yet t...

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Bibliographic Details
Published in:European journal of clinical nutrition 2018-03, Vol.72 (3), p.446-451
Main Authors: Gómez-Hoyos, Emilia, Fernández-Peña, Silvia, Cuesta, Martín, Ortolá, Ana, Matía, Pilar, Pérez-Ferre, Natalia, De Luis, Daniel, Calle-Pascual, Alfonso, Rubio, Miguel Ángel, Runkle-De la Vega, Isabelle
Format: Article
Language:English
Subjects:
692/163
692/163/2743
692/308/174
692/700/2814
Aged
Aged, 80 and over
Blood Proteins - analysis
Clinical Nutrition
Complications and side effects
Electrolytes
Epidemiology
Female
Human nutrition
Humans
Hyponatremia
Hyponatremia - blood
Hyponatremia - epidemiology
Hyponatremia - etiology
Hyponatremia - prevention & control
Internal Medicine
Male
Medicine
Medicine & Public Health
Metabolic Diseases
Middle Aged
Nutrition
Nutrition research
Osmolarity
Parenteral nutrition
Parenteral Nutrition - adverse effects
Parenteral Nutrition - statistics & numerical data
Patients
Physiological research
Prevalence
Prevalence studies (Epidemiology)
Proteins
Public Health
Retrospective Studies
Risk factors
Sodium
Sodium - blood
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Summary:Background/objectives Hyponatremia is the most common electrolyte disorder, and is associated with high-morbimortality rates. The true prevalence of hyponatremia in patients on parenteral nutrition (PN) is unknown, and the relationship between PN composition and development of hyponatremia has yet to be studied. Hypoproteinemia, a common finding in patients receiving PN, induces an overestimation of serum sodium (SNa) levels, when using indirect electrolyte methodology. Thus, SNa should be corrected for serum total protein levels (TP). The objective was to accurately determine the prevalence of hyponatremia (indirect SNa corrected for PT) and evaluate the relationship between the composition of PN and the development of hyponatremia. Subjects/methods Medical records of 222 hospitalized patients receiving total PN during a 7-month period were reviewed. Composition of PN, indirect SNa-mmol/l-, and SNa corrected for TP (SNa-TP)-mmol/l-, both upon initiation and during PN administration, were analyzed. Results Hyponatremia (SNa 
ISSN:0954-3007
1476-5640
DOI:10.1038/s41430-017-0026-5