Preclinical models for orthopedic research and bone tissue engineering

ABSTRACT In this review, we broadly define and discuss the preclinical rodent models that are used for orthopedics and bone tissue engineering. These range from implantation models typically used for biocompatibility testing and high‐throughput drug screening, through to fracture and critical defect...

Full description

Saved in:
Bibliographic Details
Published in:Journal of orthopaedic research 2018-03, Vol.36 (3), p.832-840
Main Authors: Schindeler, Aaron, Mills, Rebecca J., Bobyn, Justin D., Little, David G.
Format: Article
Language:English
Subjects:
animal model
Animals
Bone and Bones
Disease Models, Animal
fracture
Orthopedics
Tissue Engineering
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:ABSTRACT In this review, we broadly define and discuss the preclinical rodent models that are used for orthopedics and bone tissue engineering. These range from implantation models typically used for biocompatibility testing and high‐throughput drug screening, through to fracture and critical defect models used to model bone healing and severe orthopedic injuries. As well as highlighting the key methods papers describing these techniques, we provide additional commentary based on our substantive practical experience with animal surgery and in vivo experimental design. This review also briefly touches upon the descriptive and functional outcome measures and power calculations that are necessary for an informative study. Obtaining informative and relevant research outcomes can be very dependent on the model used, and we hope this evaluation of common models will serve as a primer for new researchers looking to undertake preclinical bone studies. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:832–840, 2018.
ISSN:0736-0266
1554-527X
DOI:10.1002/jor.23824