Systematic review of postoperative complications in patients with inflammatory bowel disease treated with immunomodulators

Background: This systematic review examined the use of immunomodulators and the risk of postoperative complications after abdominal surgery in patients with inflammatory bowel disease. Methods: Electronic databases (PubMed, Embase, Ingenta, Zetoc and Ovid) were searched and the reference lists in al...

Full description

Saved in:
Bibliographic Details
Published in:British journal of surgery 2006-07, Vol.93 (7), p.793-799
Main Authors: Subramanian, V., Pollok, R. C. G., Kang, J.-Y., Kumar, D.
Format: Article
Language:English
Subjects:
Aged
Antibodies, Monoclonal - adverse effects
Azathioprine - adverse effects
Biological and medical sciences
Cyclosporine - adverse effects
Gastroenterology. Liver. Pancreas. Abdomen
General aspects
Humans
Immunosuppressive Agents - administration & dosage
Immunosuppressive Agents - adverse effects
Inflammatory Bowel Diseases - drug therapy
Inflammatory Bowel Diseases - surgery
Infliximab
Medical sciences
Mercaptopurine - adverse effects
Middle Aged
Other diseases. Semiology
Postoperative Complications - etiology
Postoperative Complications - prevention & control
Risk Factors
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background: This systematic review examined the use of immunomodulators and the risk of postoperative complications after abdominal surgery in patients with inflammatory bowel disease. Methods: Electronic databases (PubMed, Embase, Ingenta, Zetoc and Ovid) were searched and the reference lists in all articles identified were hand‐searched for further relevant papers. Studies were included if they evaluated postoperative complications and defined exposure to individual immunomodulators. Results: All 11 studies that met the inclusion criteria were observational studies; two were reported only in form. Five studies reported risks associated with azathioprine, five reported risks associated with cyclosporin and three reported risks associated with infliximab. None showed an increased risk of either total or infectious complications associated with immunomodulator use. However, subgroup analysis in one study, published as an , suggested increased rates of anastomotic complications and reoperation associated with azathioprine. Conclusion: Available evidence does not suggest an increased rate of postoperative complications associated with immunomodulator use. Copyright © 2006 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd. Complications not increased
ISSN:0007-1323
1365-2168
DOI:10.1002/bjs.5375