Influence of dietary nitrate food forms on nitrate metabolism and blood pressure in healthy normotensive adults

Inorganic nitrate (NO3−) supplementation has been shown to improve cardiovascular health indices in healthy adults. The purpose of this study was to investigate how the vehicle of NO3− administration can influence NO3− metabolism and the subsequent blood pressure response. Ten healthy males consumed...

Full description

Saved in:
Bibliographic Details
Published in:Nitric oxide 2018-01, Vol.72, p.66-74
Main Authors: McDonagh, Sinead T.J., Wylie, Lee J., Webster, James M.A., Vanhatalo, Anni, Jones, Andrew M.
Format: Article
Language:English
Subjects:
Adult
Beta vulgaris
Blood pressure
Blood Pressure - drug effects
Cardiovascular health
Dietary nitrate
Dietary Supplements
Fruit and Vegetable Juices
Heart Rate - drug effects
Humans
Male
Nitrates - administration & dosage
Nitrates - metabolism
Nitrates - pharmacokinetics
Nitrite
Nitrites - analysis
Nitrites - metabolism
Pharmacokinetics
Saliva - chemistry
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c356t-f5225e215f72b793daaa20e10ab8618bf7251f02ae3ec7f70f274f0675068b453
cites cdi_FETCH-LOGICAL-c356t-f5225e215f72b793daaa20e10ab8618bf7251f02ae3ec7f70f274f0675068b453
container_end_page 74
container_issue
container_start_page 66
container_title Nitric oxide
container_volume 72
creator McDonagh, Sinead T.J.
Wylie, Lee J.
Webster, James M.A.
Vanhatalo, Anni
Jones, Andrew M.
description Inorganic nitrate (NO3−) supplementation has been shown to improve cardiovascular health indices in healthy adults. The purpose of this study was to investigate how the vehicle of NO3− administration can influence NO3− metabolism and the subsequent blood pressure response. Ten healthy males consumed an acute equimolar dose of NO3− (∼5.76 mmol) in the form of a concentrated beetroot juice drink (BR; 55 mL), a non-concentrated beetroot juice drink (BL; 456 mL) and a solid beetroot flapjack (BF; 60 g). A drink containing soluble beetroot crystals (BC; ∼1.40 mmol NO3−) and a control drink (CON; 70 mL deionised water) were also ingested. BP and plasma, salivary and urinary [NO3−] and [NO2−] were determined before and up to 24 h after ingestion. All NO3−-rich vehicles elevated plasma, salivary and urinary nitric oxide metabolites compared with baseline and CON (P
doi_str_mv 10.1016/j.niox.2017.12.001
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1975593415</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1089860317302057</els_id><sourcerecordid>1975593415</sourcerecordid><originalsourceid>FETCH-LOGICAL-c356t-f5225e215f72b793daaa20e10ab8618bf7251f02ae3ec7f70f274f0675068b453</originalsourceid><addsrcrecordid>eNp9kMtKAzEUhoMotl5ewIVk6abjSaaZC7iR4qUguNF1yMycYMpMUpNM0bc3Q7VLNznh8P0_nI-QKwYZA1bcbjJr3FfGgZUZ4xkAOyJzBlW9qArGjg9_yGfkLIQNACzzqjglM15znotKzIlbW92PaFukTtPOYFT-m1oTvYpItXNdevwQqLOH7ZCgxvUmDFTZjjb9RG09hjB6pMbSD1R9_Eg1Keki2mB2SFU39jFckBOt-oCXv_OcvD8-vK2eFy-vT-vV_cuizUURF1pwLpAzoUvelHXeKaU4IAPVpNuqJq0F08AV5tiWugTNy6WGohRQVM1S5OfkZt-79e5zxBDlYEKLfa8sujFIVpdC1PmSTSjfo613IXjUcuvNkDRIBnISLTdyEi0n0ZJxmUSn0PVv_9gM2B0if2YTcLcHMF25M-hlaM3kuTMe2yg7Z_7r_wH2jpDj</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1975593415</pqid></control><display><type>article</type><title>Influence of dietary nitrate food forms on nitrate metabolism and blood pressure in healthy normotensive adults</title><source>Elsevier</source><creator>McDonagh, Sinead T.J. ; Wylie, Lee J. ; Webster, James M.A. ; Vanhatalo, Anni ; Jones, Andrew M.</creator><creatorcontrib>McDonagh, Sinead T.J. ; Wylie, Lee J. ; Webster, James M.A. ; Vanhatalo, Anni ; Jones, Andrew M.</creatorcontrib><description>Inorganic nitrate (NO3−) supplementation has been shown to improve cardiovascular health indices in healthy adults. The purpose of this study was to investigate how the vehicle of NO3− administration can influence NO3− metabolism and the subsequent blood pressure response. Ten healthy males consumed an acute equimolar dose of NO3− (∼5.76 mmol) in the form of a concentrated beetroot juice drink (BR; 55 mL), a non-concentrated beetroot juice drink (BL; 456 mL) and a solid beetroot flapjack (BF; 60 g). A drink containing soluble beetroot crystals (BC; ∼1.40 mmol NO3−) and a control drink (CON; 70 mL deionised water) were also ingested. BP and plasma, salivary and urinary [NO3−] and [NO2−] were determined before and up to 24 h after ingestion. All NO3−-rich vehicles elevated plasma, salivary and urinary nitric oxide metabolites compared with baseline and CON (P&lt;0.05). The peak increases in plasma [NO2−] were greater in BF (371 ± 136 nM) and BR (369 ± 167 nM) compared to BL (283 ± 93 nM; all P&lt;0.05) and BC (232 ± 51 nM). BR, but not BF, BL and BC, reduced systolic (∼5 mmHg) and mean arterial pressure (∼3–4 mmHg; P&lt;0.05), whereas BF reduced diastolic BP (∼4 mmHg; P &lt; 0.05). Although plasma [NO2−] was elevated in all conditions, the consumption of a small, concentrated NO3−-rich fluid (BR) was the most effective means of reducing BP. These findings have implications for the use of dietary NO3−supplements when the main objective is to maintain or improve indices of cardiovascular health. •We investigated how the vehicle of NO3− administration can influence NO3− metabolism and resting blood pressure (BP).•Subjects ingested 5.76 mmol NO3− in concentrated beetroot juice (BR), standard beetroot juice (BL) and a beetroot flapjack (BF).•BR reduced systolic (~5 mmHg) and mean arterial BP (~3–4 mmHg) and BF reduced diastolic BP (~4 mmHg).•The ingestion of a small, concentrated NO3−-rich fluid (BR) was the most effective means of reducing BP.</description><identifier>ISSN: 1089-8603</identifier><identifier>EISSN: 1089-8611</identifier><identifier>DOI: 10.1016/j.niox.2017.12.001</identifier><identifier>PMID: 29223585</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Beta vulgaris ; Blood pressure ; Blood Pressure - drug effects ; Cardiovascular health ; Dietary nitrate ; Dietary Supplements ; Fruit and Vegetable Juices ; Heart Rate - drug effects ; Humans ; Male ; Nitrates - administration &amp; dosage ; Nitrates - metabolism ; Nitrates - pharmacokinetics ; Nitrite ; Nitrites - analysis ; Nitrites - metabolism ; Pharmacokinetics ; Saliva - chemistry</subject><ispartof>Nitric oxide, 2018-01, Vol.72, p.66-74</ispartof><rights>2017 Elsevier Inc.</rights><rights>Copyright © 2017 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-f5225e215f72b793daaa20e10ab8618bf7251f02ae3ec7f70f274f0675068b453</citedby><cites>FETCH-LOGICAL-c356t-f5225e215f72b793daaa20e10ab8618bf7251f02ae3ec7f70f274f0675068b453</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29223585$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>McDonagh, Sinead T.J.</creatorcontrib><creatorcontrib>Wylie, Lee J.</creatorcontrib><creatorcontrib>Webster, James M.A.</creatorcontrib><creatorcontrib>Vanhatalo, Anni</creatorcontrib><creatorcontrib>Jones, Andrew M.</creatorcontrib><title>Influence of dietary nitrate food forms on nitrate metabolism and blood pressure in healthy normotensive adults</title><title>Nitric oxide</title><addtitle>Nitric Oxide</addtitle><description>Inorganic nitrate (NO3−) supplementation has been shown to improve cardiovascular health indices in healthy adults. The purpose of this study was to investigate how the vehicle of NO3− administration can influence NO3− metabolism and the subsequent blood pressure response. Ten healthy males consumed an acute equimolar dose of NO3− (∼5.76 mmol) in the form of a concentrated beetroot juice drink (BR; 55 mL), a non-concentrated beetroot juice drink (BL; 456 mL) and a solid beetroot flapjack (BF; 60 g). A drink containing soluble beetroot crystals (BC; ∼1.40 mmol NO3−) and a control drink (CON; 70 mL deionised water) were also ingested. BP and plasma, salivary and urinary [NO3−] and [NO2−] were determined before and up to 24 h after ingestion. All NO3−-rich vehicles elevated plasma, salivary and urinary nitric oxide metabolites compared with baseline and CON (P&lt;0.05). The peak increases in plasma [NO2−] were greater in BF (371 ± 136 nM) and BR (369 ± 167 nM) compared to BL (283 ± 93 nM; all P&lt;0.05) and BC (232 ± 51 nM). BR, but not BF, BL and BC, reduced systolic (∼5 mmHg) and mean arterial pressure (∼3–4 mmHg; P&lt;0.05), whereas BF reduced diastolic BP (∼4 mmHg; P &lt; 0.05). Although plasma [NO2−] was elevated in all conditions, the consumption of a small, concentrated NO3−-rich fluid (BR) was the most effective means of reducing BP. These findings have implications for the use of dietary NO3−supplements when the main objective is to maintain or improve indices of cardiovascular health. •We investigated how the vehicle of NO3− administration can influence NO3− metabolism and resting blood pressure (BP).•Subjects ingested 5.76 mmol NO3− in concentrated beetroot juice (BR), standard beetroot juice (BL) and a beetroot flapjack (BF).•BR reduced systolic (~5 mmHg) and mean arterial BP (~3–4 mmHg) and BF reduced diastolic BP (~4 mmHg).•The ingestion of a small, concentrated NO3−-rich fluid (BR) was the most effective means of reducing BP.</description><subject>Adult</subject><subject>Beta vulgaris</subject><subject>Blood pressure</subject><subject>Blood Pressure - drug effects</subject><subject>Cardiovascular health</subject><subject>Dietary nitrate</subject><subject>Dietary Supplements</subject><subject>Fruit and Vegetable Juices</subject><subject>Heart Rate - drug effects</subject><subject>Humans</subject><subject>Male</subject><subject>Nitrates - administration &amp; dosage</subject><subject>Nitrates - metabolism</subject><subject>Nitrates - pharmacokinetics</subject><subject>Nitrite</subject><subject>Nitrites - analysis</subject><subject>Nitrites - metabolism</subject><subject>Pharmacokinetics</subject><subject>Saliva - chemistry</subject><issn>1089-8603</issn><issn>1089-8611</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kMtKAzEUhoMotl5ewIVk6abjSaaZC7iR4qUguNF1yMycYMpMUpNM0bc3Q7VLNznh8P0_nI-QKwYZA1bcbjJr3FfGgZUZ4xkAOyJzBlW9qArGjg9_yGfkLIQNACzzqjglM15znotKzIlbW92PaFukTtPOYFT-m1oTvYpItXNdevwQqLOH7ZCgxvUmDFTZjjb9RG09hjB6pMbSD1R9_Eg1Keki2mB2SFU39jFckBOt-oCXv_OcvD8-vK2eFy-vT-vV_cuizUURF1pwLpAzoUvelHXeKaU4IAPVpNuqJq0F08AV5tiWugTNy6WGohRQVM1S5OfkZt-79e5zxBDlYEKLfa8sujFIVpdC1PmSTSjfo613IXjUcuvNkDRIBnISLTdyEi0n0ZJxmUSn0PVv_9gM2B0if2YTcLcHMF25M-hlaM3kuTMe2yg7Z_7r_wH2jpDj</recordid><startdate>20180130</startdate><enddate>20180130</enddate><creator>McDonagh, Sinead T.J.</creator><creator>Wylie, Lee J.</creator><creator>Webster, James M.A.</creator><creator>Vanhatalo, Anni</creator><creator>Jones, Andrew M.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20180130</creationdate><title>Influence of dietary nitrate food forms on nitrate metabolism and blood pressure in healthy normotensive adults</title><author>McDonagh, Sinead T.J. ; Wylie, Lee J. ; Webster, James M.A. ; Vanhatalo, Anni ; Jones, Andrew M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-f5225e215f72b793daaa20e10ab8618bf7251f02ae3ec7f70f274f0675068b453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Beta vulgaris</topic><topic>Blood pressure</topic><topic>Blood Pressure - drug effects</topic><topic>Cardiovascular health</topic><topic>Dietary nitrate</topic><topic>Dietary Supplements</topic><topic>Fruit and Vegetable Juices</topic><topic>Heart Rate - drug effects</topic><topic>Humans</topic><topic>Male</topic><topic>Nitrates - administration &amp; dosage</topic><topic>Nitrates - metabolism</topic><topic>Nitrates - pharmacokinetics</topic><topic>Nitrite</topic><topic>Nitrites - analysis</topic><topic>Nitrites - metabolism</topic><topic>Pharmacokinetics</topic><topic>Saliva - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McDonagh, Sinead T.J.</creatorcontrib><creatorcontrib>Wylie, Lee J.</creatorcontrib><creatorcontrib>Webster, James M.A.</creatorcontrib><creatorcontrib>Vanhatalo, Anni</creatorcontrib><creatorcontrib>Jones, Andrew M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nitric oxide</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McDonagh, Sinead T.J.</au><au>Wylie, Lee J.</au><au>Webster, James M.A.</au><au>Vanhatalo, Anni</au><au>Jones, Andrew M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of dietary nitrate food forms on nitrate metabolism and blood pressure in healthy normotensive adults</atitle><jtitle>Nitric oxide</jtitle><addtitle>Nitric Oxide</addtitle><date>2018-01-30</date><risdate>2018</risdate><volume>72</volume><spage>66</spage><epage>74</epage><pages>66-74</pages><issn>1089-8603</issn><eissn>1089-8611</eissn><abstract>Inorganic nitrate (NO3−) supplementation has been shown to improve cardiovascular health indices in healthy adults. The purpose of this study was to investigate how the vehicle of NO3− administration can influence NO3− metabolism and the subsequent blood pressure response. Ten healthy males consumed an acute equimolar dose of NO3− (∼5.76 mmol) in the form of a concentrated beetroot juice drink (BR; 55 mL), a non-concentrated beetroot juice drink (BL; 456 mL) and a solid beetroot flapjack (BF; 60 g). A drink containing soluble beetroot crystals (BC; ∼1.40 mmol NO3−) and a control drink (CON; 70 mL deionised water) were also ingested. BP and plasma, salivary and urinary [NO3−] and [NO2−] were determined before and up to 24 h after ingestion. All NO3−-rich vehicles elevated plasma, salivary and urinary nitric oxide metabolites compared with baseline and CON (P&lt;0.05). The peak increases in plasma [NO2−] were greater in BF (371 ± 136 nM) and BR (369 ± 167 nM) compared to BL (283 ± 93 nM; all P&lt;0.05) and BC (232 ± 51 nM). BR, but not BF, BL and BC, reduced systolic (∼5 mmHg) and mean arterial pressure (∼3–4 mmHg; P&lt;0.05), whereas BF reduced diastolic BP (∼4 mmHg; P &lt; 0.05). Although plasma [NO2−] was elevated in all conditions, the consumption of a small, concentrated NO3−-rich fluid (BR) was the most effective means of reducing BP. These findings have implications for the use of dietary NO3−supplements when the main objective is to maintain or improve indices of cardiovascular health. •We investigated how the vehicle of NO3− administration can influence NO3− metabolism and resting blood pressure (BP).•Subjects ingested 5.76 mmol NO3− in concentrated beetroot juice (BR), standard beetroot juice (BL) and a beetroot flapjack (BF).•BR reduced systolic (~5 mmHg) and mean arterial BP (~3–4 mmHg) and BF reduced diastolic BP (~4 mmHg).•The ingestion of a small, concentrated NO3−-rich fluid (BR) was the most effective means of reducing BP.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>29223585</pmid><doi>10.1016/j.niox.2017.12.001</doi><tpages>9</tpages></addata></record>
fulltext fulltext
identifier ISSN: 1089-8603
ispartof Nitric oxide, 2018-01, Vol.72, p.66-74
issn 1089-8603
1089-8611
language eng
recordid cdi_proquest_miscellaneous_1975593415
source Elsevier
subjects Adult
Beta vulgaris
Blood pressure
Blood Pressure - drug effects
Cardiovascular health
Dietary nitrate
Dietary Supplements
Fruit and Vegetable Juices
Heart Rate - drug effects
Humans
Male
Nitrates - administration & dosage
Nitrates - metabolism
Nitrates - pharmacokinetics
Nitrite
Nitrites - analysis
Nitrites - metabolism
Pharmacokinetics
Saliva - chemistry
title Influence of dietary nitrate food forms on nitrate metabolism and blood pressure in healthy normotensive adults
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T20%3A54%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Influence%20of%20dietary%20nitrate%20food%20forms%20on%20nitrate%20metabolism%20and%20blood%20pressure%20in%20healthy%20normotensive%20adults&rft.jtitle=Nitric%20oxide&rft.au=McDonagh,%20Sinead%20T.J.&rft.date=2018-01-30&rft.volume=72&rft.spage=66&rft.epage=74&rft.pages=66-74&rft.issn=1089-8603&rft.eissn=1089-8611&rft_id=info:doi/10.1016/j.niox.2017.12.001&rft_dat=%3Cproquest_cross%3E1975593415%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c356t-f5225e215f72b793daaa20e10ab8618bf7251f02ae3ec7f70f274f0675068b453%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1975593415&rft_id=info:pmid/29223585&rfr_iscdi=true