Definitive (chemo)radiotherapy is a curative alternative for standard of care in advanced stage squamous cell carcinoma of the oral cavity

•We aimed to compare two treatment modalities for advanced oral cavity carcinoma.•We retrospectively analyzed the outcomes of definitive CRT vs. surgery + PORT.•Tumor stage and local tumor diameter were significantly larger in the CRT group.•After adjusting for confounders, surgery resulted in bette...

Full description

Saved in:
Bibliographic Details
Published in:Oral oncology 2017-12, Vol.75, p.163-168
Main Authors: Elbers, Joris B.W., Al-Mamgani, Abrahim, Paping, Danique, van den Brekel, Michiel W.M., Jóźwiak, Katarzyna, de Boer, J.P., Karakullukcu, Baris, Verheij, Marcel, Zuur, Charlotte L.
Format: Article
Language:English
Subjects:
Adult
Advanced stage
Carcinoma
Carcinoma, Squamous Cell - pathology
Carcinoma, Squamous Cell - surgery
Carcinoma, Squamous Cell - therapy
Chemoradiotherapy
Disease-Free Survival
Female
General surgery
Head and neck neoplasms
Humans
Local
Male
Middle Aged
Mouth Neoplasms - pathology
Mouth Neoplasms - surgery
Mouth Neoplasms - therapy
Neoplasm recurrence
Neoplasm Staging
Oral cavity
Prognosis
Radiotherapy
Retrospective Studies
Squamous cell
Standard of Care
Survival
Treatment Outcome
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:•We aimed to compare two treatment modalities for advanced oral cavity carcinoma.•We retrospectively analyzed the outcomes of definitive CRT vs. surgery + PORT.•Tumor stage and local tumor diameter were significantly larger in the CRT group.•After adjusting for confounders, surgery resulted in better LRC.•However, definitive CRT is a curative alternative when surgery is not feasible. To compare outcome after definitive (chemo)radiotherapy (CRT group) with standard of care (surgery group) for advanced stage oral cavity carcinoma (OCC). Although definitive (chemo)radiotherapy is assumed to be inferior to surgery with regard to disease control, data on outcome of this approach are scarce. Retrospective analysis by chart review (2000–2013). Endpoints were locoregional control (LRC), disease-free survival (DFS), disease specific survival (DSS) and overall survival (OS). Between the CRT-group (n = 100) and Surgery-group (n = 109), baseline characteristics were equally distributed except stage and local tumor diameter (all p ≤ .001). In the CRT group, at 5 years the LRC rate was 49%, DFS 22%, DSS 39% and OS 22%. In the surgery group, at 5 years the LRC rate was 77%, DFS 45%, DSS 64% and OS 45%. The survival curves of the two groups significantly differed for LRC (p 
ISSN:1368-8375
1879-0593
DOI:10.1016/j.oraloncology.2017.11.006