Occupational Exposure to Immunologically Active Agents and Risk for Lymphoma

Objectives: We evaluated whether occupational exposure to high molecular weight agents that are associated with asthma and that act predominantly through an immunoglobulin E (IgE)–dependent hypersensitivity mechanism is also associated with risk for specific lymphoma types. Methods: The Spanish lymp...

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Published in:Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2004-11, Vol.13 (11), p.1814-1818
Main Authors: KOGEVINAS, Manolis, ZOCK, Jan-Paul, ALVARO, Tomas, GARCIA-VILLANUEVA, Mercedes, DOMINGO-DOMENECH, Eva, KENNEDY, Susan, MARTINEZ-MAZA, Otoniel, DE SANJOSE, Silvia
Format: Article
Language:English
Subjects:
Asthma - chemically induced
Asthma - immunology
Biological and medical sciences
Case-Control Studies
Female
Hematologic and hematopoietic diseases
Humans
Immunoglobulin E - immunology
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Lymphoma - chemically induced
Lymphoma - epidemiology
Lymphoma - immunology
Male
Medical sciences
Middle Aged
Molecular Weight
Occupational Exposure - adverse effects
Risk Factors
Spain - epidemiology
Tumors
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Summary:Objectives: We evaluated whether occupational exposure to high molecular weight agents that are associated with asthma and that act predominantly through an immunoglobulin E (IgE)–dependent hypersensitivity mechanism is also associated with risk for specific lymphoma types. Methods: The Spanish lymphoma case-control study includes 519 newly diagnosed cases of lymphoid neoplasms and 554 hospital controls ages 20 to 80 years. Lymphomas were histologically or cytologically confirmed and classified according to the WHO classification. Lifetime occupational exposure to seven high molecular weight agents such as latex was evaluated through an asthma-specific job-exposure matrix and validated by an industrial hygienist. Odds ratios (OR) and 95% confidence intervals (95% CI) were adjusted for age, sex, hospital, and occupational exposures. Results: Subjects exposed to high molecular weight agents had an increased risk for Hodgkin's lymphoma (OR, 2.27; 95% CI, 0.93-5.50), particularly nodular sclerosis (OR, 3.22; 95% CI, 1.14-9.09). ORs did not increase with duration of exposure to these agents. Exposure to high molecular weight agents was not associated with risk of other B-cell lymphomas; for most specific subcategories of B-cell lymphoma, ORs were below unity. A slightly increased OR (95% CI) was seen for mycosis fungoides [1.60 (0.53-4.84)], although overall there was no increased risk for T-cell lymphomas. Conclusions: Exposure to immunologically active agents among clinically immunocompetent subjects was associated with risk for Hodgkin's lymphoma.
ISSN:1055-9965
1538-7755
DOI:10.1158/1055-9965.1814.13.11