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Relationship between serum anti‐varicella zoster virus antibody titer and time from onset of herpes zoster
Herpes zoster is an internal reactivation of varicella zoster virus, and its onset depends on immunity against this virus. We have previously reported that antiviral antibody titers are inversely correlated with patient numbers. In this study, we hypothesized that patients with higher titers may be...
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| Published in: | Journal of dermatology 2018-02, Vol.45 (2), p.189-193 |
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| container_end_page | 193 |
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| container_title | Journal of dermatology |
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| creator | Ihara, Honoka Miyachi, Motoko Imafuku, Shinichi |
| description | Herpes zoster is an internal reactivation of varicella zoster virus, and its onset depends on immunity against this virus. We have previously reported that antiviral antibody titers are inversely correlated with patient numbers. In this study, we hypothesized that patients with higher titers may be late visitors to the clinic, whose antibodies were already boosted at presentation because of the time lapse between onset of zoster and measurement of antibodies. We analyzed antibody titers of patients with acute herpes zoster who visited Fukuoka University Hospital from January 2009 to May 2016 (n = 141, 62 males and 79 females). Varicella zoster virus‐specific immunoglobulin G, M and complement fixation tests were positive in 93.9%, 12.0% and 64.2% of the patients, respectively. Immunoglobulin G and complement fixation titers were strongly correlated (Spearman's r = 0.8634, P |
| doi_str_mv | 10.1111/1346-8138.14168 |
| format | article |
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We have previously reported that antiviral antibody titers are inversely correlated with patient numbers. In this study, we hypothesized that patients with higher titers may be late visitors to the clinic, whose antibodies were already boosted at presentation because of the time lapse between onset of zoster and measurement of antibodies. We analyzed antibody titers of patients with acute herpes zoster who visited Fukuoka University Hospital from January 2009 to May 2016 (n = 141, 62 males and 79 females). Varicella zoster virus‐specific immunoglobulin G, M and complement fixation tests were positive in 93.9%, 12.0% and 64.2% of the patients, respectively. Immunoglobulin G and complement fixation titers were strongly correlated (Spearman's r = 0.8634, P < 0.0001). Patients with high immunoglobulin G and complement fixation titers were immunoglobulin M‐negative. Unexpectedly, immunoglobulin G and complement fixation titers showed large inter‐subject variation, and were only weakly correlated with onset–measurement time lapse. Patients with consecutive tests tended to show increasing immunoglobulin G and complement fixation titers. Our data suggest that herpes zoster preferentially occurs in patients with low immunoglobulin G and complement fixation titers, and subsequently causes antibody elevation. However, the timing of elevation varies and can be as late as 10 days after zoster. The large variation in antibody titer over the time from onset to testing suggests that some mechanism exists that resists the local breakthrough of virus in the skin, and so delays the onset of blisters.</description><identifier>ISSN: 0385-2407</identifier><identifier>EISSN: 1346-8138</identifier><identifier>DOI: 10.1111/1346-8138.14168</identifier><identifier>PMID: 29239011</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antibodies, Viral - blood ; Antibodies, Viral - immunology ; antibody titer ; Antiviral drugs ; Chicken pox ; Child ; Child, Preschool ; Complement fixation ; Complement Fixation Tests ; Female ; Herpes zoster ; Herpes Zoster - blood ; Herpes Zoster - immunology ; Herpesvirus 3, Human - immunology ; Humans ; Immunoglobulin G ; Immunoglobulin G - blood ; Immunoglobulin G - immunology ; Immunoglobulin M ; Immunoglobulins ; Infant ; Male ; Middle Aged ; Retrospective Studies ; Skin ; Time Factors ; Varicella ; varicella zoster virus ; Young Adult</subject><ispartof>Journal of dermatology, 2018-02, Vol.45 (2), p.189-193</ispartof><rights>2017 Japanese Dermatological Association</rights><rights>2017 Japanese Dermatological Association.</rights><rights>Copyright © 2018 Japanese Dermatological Association</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4618-7ca80912759bcc7dc2f9afe86dffa5dcf1b22a4f77929c8a3b73c2d65132fbb73</citedby><cites>FETCH-LOGICAL-c4618-7ca80912759bcc7dc2f9afe86dffa5dcf1b22a4f77929c8a3b73c2d65132fbb73</cites><orcidid>0000-0001-8568-4349</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29239011$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ihara, Honoka</creatorcontrib><creatorcontrib>Miyachi, Motoko</creatorcontrib><creatorcontrib>Imafuku, Shinichi</creatorcontrib><title>Relationship between serum anti‐varicella zoster virus antibody titer and time from onset of herpes zoster</title><title>Journal of dermatology</title><addtitle>J Dermatol</addtitle><description>Herpes zoster is an internal reactivation of varicella zoster virus, and its onset depends on immunity against this virus. We have previously reported that antiviral antibody titers are inversely correlated with patient numbers. In this study, we hypothesized that patients with higher titers may be late visitors to the clinic, whose antibodies were already boosted at presentation because of the time lapse between onset of zoster and measurement of antibodies. We analyzed antibody titers of patients with acute herpes zoster who visited Fukuoka University Hospital from January 2009 to May 2016 (n = 141, 62 males and 79 females). Varicella zoster virus‐specific immunoglobulin G, M and complement fixation tests were positive in 93.9%, 12.0% and 64.2% of the patients, respectively. Immunoglobulin G and complement fixation titers were strongly correlated (Spearman's r = 0.8634, P < 0.0001). Patients with high immunoglobulin G and complement fixation titers were immunoglobulin M‐negative. Unexpectedly, immunoglobulin G and complement fixation titers showed large inter‐subject variation, and were only weakly correlated with onset–measurement time lapse. Patients with consecutive tests tended to show increasing immunoglobulin G and complement fixation titers. Our data suggest that herpes zoster preferentially occurs in patients with low immunoglobulin G and complement fixation titers, and subsequently causes antibody elevation. However, the timing of elevation varies and can be as late as 10 days after zoster. The large variation in antibody titer over the time from onset to testing suggests that some mechanism exists that resists the local breakthrough of virus in the skin, and so delays the onset of blisters.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antibodies, Viral - blood</subject><subject>Antibodies, Viral - immunology</subject><subject>antibody titer</subject><subject>Antiviral drugs</subject><subject>Chicken pox</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Complement fixation</subject><subject>Complement Fixation Tests</subject><subject>Female</subject><subject>Herpes zoster</subject><subject>Herpes Zoster - blood</subject><subject>Herpes Zoster - immunology</subject><subject>Herpesvirus 3, Human - immunology</subject><subject>Humans</subject><subject>Immunoglobulin G</subject><subject>Immunoglobulin G - blood</subject><subject>Immunoglobulin G - immunology</subject><subject>Immunoglobulin M</subject><subject>Immunoglobulins</subject><subject>Infant</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Retrospective Studies</subject><subject>Skin</subject><subject>Time Factors</subject><subject>Varicella</subject><subject>varicella zoster virus</subject><subject>Young Adult</subject><issn>0385-2407</issn><issn>1346-8138</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNqFkctu1TAQhi0EoofCmh2yxIZNWo8Tx_YSteVSVUKqytpynLHqKokPdtLqsOIReEaeBJ8LXXSDN-OZ-eaX_Q8hb4GdQDmnUDdtpaBWJ9BAq56R1WPlOVmxWomKN0wekVc53zHGtQD2khxxzWvNAFZkuMbBziFO-TasaYfzA-JEM6ZlpHaaw59fv-9tCg6HwdKfMc-Y6H1IS951u9hv6By2RTv15TYi9SmOtOjhTKOnt5jWmA-Tr8kLb4eMbw7xmHz_dHFz9qW6-vb569nHq8o1LahKOquYBi6F7pyTveNeW4-q7b23onceOs5t46XUXDtl607WjvetgJr7riTH5MNed53ijwXzbMaQd1-YMC7ZgJYSFCgpCvr-CXoXlzSV1xVK11woIXihTveUSzHnhN6sUxht2hhgZrsIs7XdbG03u0WUiXcH3aUbsX_k_zlfALEHHsKAm__pmcvzi73wXw8ElQ8</recordid><startdate>201802</startdate><enddate>201802</enddate><creator>Ihara, Honoka</creator><creator>Miyachi, Motoko</creator><creator>Imafuku, Shinichi</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8568-4349</orcidid></search><sort><creationdate>201802</creationdate><title>Relationship between serum anti‐varicella zoster virus antibody titer and time from onset of herpes zoster</title><author>Ihara, Honoka ; Miyachi, Motoko ; Imafuku, Shinichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4618-7ca80912759bcc7dc2f9afe86dffa5dcf1b22a4f77929c8a3b73c2d65132fbb73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antibodies, Viral - blood</topic><topic>Antibodies, Viral - immunology</topic><topic>antibody titer</topic><topic>Antiviral drugs</topic><topic>Chicken pox</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Complement fixation</topic><topic>Complement Fixation Tests</topic><topic>Female</topic><topic>Herpes zoster</topic><topic>Herpes Zoster - blood</topic><topic>Herpes Zoster - immunology</topic><topic>Herpesvirus 3, Human - immunology</topic><topic>Humans</topic><topic>Immunoglobulin G</topic><topic>Immunoglobulin G - blood</topic><topic>Immunoglobulin G - immunology</topic><topic>Immunoglobulin M</topic><topic>Immunoglobulins</topic><topic>Infant</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Retrospective Studies</topic><topic>Skin</topic><topic>Time Factors</topic><topic>Varicella</topic><topic>varicella zoster virus</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ihara, Honoka</creatorcontrib><creatorcontrib>Miyachi, Motoko</creatorcontrib><creatorcontrib>Imafuku, Shinichi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ihara, Honoka</au><au>Miyachi, Motoko</au><au>Imafuku, Shinichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between serum anti‐varicella zoster virus antibody titer and time from onset of herpes zoster</atitle><jtitle>Journal of dermatology</jtitle><addtitle>J Dermatol</addtitle><date>2018-02</date><risdate>2018</risdate><volume>45</volume><issue>2</issue><spage>189</spage><epage>193</epage><pages>189-193</pages><issn>0385-2407</issn><eissn>1346-8138</eissn><abstract>Herpes zoster is an internal reactivation of varicella zoster virus, and its onset depends on immunity against this virus. We have previously reported that antiviral antibody titers are inversely correlated with patient numbers. In this study, we hypothesized that patients with higher titers may be late visitors to the clinic, whose antibodies were already boosted at presentation because of the time lapse between onset of zoster and measurement of antibodies. We analyzed antibody titers of patients with acute herpes zoster who visited Fukuoka University Hospital from January 2009 to May 2016 (n = 141, 62 males and 79 females). Varicella zoster virus‐specific immunoglobulin G, M and complement fixation tests were positive in 93.9%, 12.0% and 64.2% of the patients, respectively. Immunoglobulin G and complement fixation titers were strongly correlated (Spearman's r = 0.8634, P < 0.0001). Patients with high immunoglobulin G and complement fixation titers were immunoglobulin M‐negative. Unexpectedly, immunoglobulin G and complement fixation titers showed large inter‐subject variation, and were only weakly correlated with onset–measurement time lapse. Patients with consecutive tests tended to show increasing immunoglobulin G and complement fixation titers. Our data suggest that herpes zoster preferentially occurs in patients with low immunoglobulin G and complement fixation titers, and subsequently causes antibody elevation. However, the timing of elevation varies and can be as late as 10 days after zoster. The large variation in antibody titer over the time from onset to testing suggests that some mechanism exists that resists the local breakthrough of virus in the skin, and so delays the onset of blisters.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>29239011</pmid><doi>10.1111/1346-8138.14168</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0001-8568-4349</orcidid></addata></record> |
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| ispartof | Journal of dermatology, 2018-02, Vol.45 (2), p.189-193 |
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| subjects | Adolescent Adult Aged Aged, 80 and over Antibodies, Viral - blood Antibodies, Viral - immunology antibody titer Antiviral drugs Chicken pox Child Child, Preschool Complement fixation Complement Fixation Tests Female Herpes zoster Herpes Zoster - blood Herpes Zoster - immunology Herpesvirus 3, Human - immunology Humans Immunoglobulin G Immunoglobulin G - blood Immunoglobulin G - immunology Immunoglobulin M Immunoglobulins Infant Male Middle Aged Retrospective Studies Skin Time Factors Varicella varicella zoster virus Young Adult |
| title | Relationship between serum anti‐varicella zoster virus antibody titer and time from onset of herpes zoster |
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