Ultrasound surveillance for cholangiocarcinoma in an endemic area: A prove of survival benefits

Background and Aim Cholangiocarcinoma (CCA) is an aggressive malignancy with rapid progression and poor prognosis. Abdominal ultrasound surveillance may detect early‐stage malignancy and improve surgical outcome. However, little data exist on the benefits of abdominal ultrasound surveillance in popu...

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Bibliographic Details
Published in:Journal of gastroenterology and hepatology 2018-07, Vol.33 (7), p.1383-1388
Main Authors: Siripongsakun, Surachate, Vidhyarkorn, Sirachat, Charuswattanakul, Sirivipa, Mekraksakit, Poemlarp, Sungkasubun, Prakongboon, Yodkhunnathum, Nuphat, Tangruangkiat, Sutthirak, Ritlumlert, Napat, Sricharunrat, Thaniya, Jaroenpatarapesaj, Sirima, Soonklang, Kamonwan, Kulthanmanusorn, Anond, Auewarakul, Chirayu U, Mahidol, Chulabhorn
Format: Article
Language:English
Subjects:
Abdomen
Alanine
Alanine transaminase
biliary neoplasms
Cholangiocarcinoma
epidemiology
liver tumors
Malignancy
malignant (non‐HCC)
Medical prognosis
Mortality
Multivariate analysis
Surveillance
Survival
Tumors
Ultrasonic imaging
Ultrasound
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Summary:Background and Aim Cholangiocarcinoma (CCA) is an aggressive malignancy with rapid progression and poor prognosis. Abdominal ultrasound surveillance may detect early‐stage malignancy and improve surgical outcome. However, little data exist on the benefits of abdominal ultrasound surveillance in populations at high risk for CCA development in an endemic area. This study compared survival outcomes of CCA patients recruited through abdominal ultrasound surveillance program and those presented to the hospital independent of surveillance. Methods The surveillance population‐based cohort was 4225 villagers in Northern Thailand, aged 30–60 years, who consented to a 5‐year abdominal ultrasound surveillance program, which included interval ultrasound examinations every 6 months. The non‐surveillance cohort was hospital‐based CCA patients diagnosed during April 2007 to November 2015. Numbers of operable tumors, percentages of R0 resection, and survival analyses were compared between the two cohorts. Results There were 48 and 192 CCA patients in the surveillance and the non‐surveillance cohorts, respectively. Of these, 37/48 (77.1%) and 22/192 (11.5%) were in an operable stage and R0 resections performed in 36/48 (97.3%) and 14/192 (63.6%), respectively. The median survival in each group was 31.8 and 6.7 months, respectively (with correction of lead time bias) (P 
ISSN:0815-9319
1440-1746
DOI:10.1111/jgh.14074