Clinical Surveillance After Macroscopically Complete Surgery for Low-Grade Appendiceal Mucinous Neoplasms (LAMN) with or Without Limited Peritoneal Spread: Long-Term Results in a Prospective Series

• Published in: Annals of surgical oncology 2018-04, Vol.25 (4), p.878-884
• Main Authors: Guaglio, Marcello, Sinukumar, Snita, Kusamura, Shigeki, Milione, Massimo, Pietrantonio, Filippo, Battaglia, Luigi, Guadagni, Stefano, Baratti, Dario, Deraco, Marcello
• Format: Article
• Language: English
• Subjects: Adenocarcinoma, Mucinous - diagnostic imaging; Adenocarcinoma, Mucinous - pathology; Adenocarcinoma, Mucinous - surgery; Adolescent; Adult; Aged; Appendectomy; Appendectomy - methods; Appendiceal Neoplasms - diagnostic imaging; Appendiceal Neoplasms - pathology; Appendiceal Neoplasms - surgery; Appendix; Chemotherapy; Computed tomography; Cytoreduction Surgical Procedures - methods; Female; Follow-Up Studies; Gastrointestinal Oncology; Humans; Hysterectomy; Male; Medicine; Medicine & Public Health; Middle Aged; Mucin; Neoplasm Recurrence, Local - diagnostic imaging; Neoplasm Recurrence, Local - pathology; Neoplasm Recurrence, Local - surgery; Oncology; Ovariectomy; Pelvis; Peritoneal Neoplasms - diagnostic imaging; Peritoneal Neoplasms - pathology; Peritoneal Neoplasms - surgery; Peritoneum; Prognosis; Prospective Studies; Rupture; Surgery; Surgical Oncology; Surveillance; Survival Rate; Thorax; Tomography, X-Ray Computed - methods; Tumor markers; Young Adult
• ISSN: 1068-9265; 1534-4681
• DOI: 10.1245/s10434-017-6305-5

Background Low-grade appendiceal mucinous neoplasm (LAMN) is the most common primary lesion of pseudomyxoma peritonei, a disease whose standard treatment is cytoreduction and hyperthermic intraperitoneal chemotherapy. The optimal management of LAMN is not well defined. This study prospectively assessed a clinical surveillance strategy for LAMN with or without limited peritoneal spread. Methods During 2003–2017, the study prospectively enrolled 41 patients treated by macroscopically complete surgery for LAMN with or without limited peritoneal spread (pelvis and right lower quadrant). Follow-up assessment included thoracic-abdomino-pelvic computed tomography scan and serum tumor markers scheduled after surgery, then every 6 months for 5 years, and yearly thereafter. All specimens were reviewed by a dedicated pathologist. Results Appendectomy and five right colectomies were performed for 36 patients. Nine patients also underwent macroscopically complete cytoreduction of mucinous peritoneal disease, and four patients had hysterectomy plus bilateral salphingo-oophorectomy. Appendiceal rupture was evaluable in 38 of the 41 patients, being present in 21 patients (51.2%). Mucin, cells, or both outside the appendix were observed in 24 patients (58.5%). The median follow-up period was 58 months (range 9.3–162 months). The 5-year recurrence-free survival rate was 95.1%. Only two patients experienced peritoneal recurrences (4.9%), respectively 18 and 22 months after appendectomy. Their primary lesions were LAMNs with and without appendix wall rupture or extra-appendiceal mucin, respectively. No death occurred. Conclusion These findings strongly suggest that radically resected LAMN, even with limited peritoneal spread, carries a low recurrence risk. Furthermore, appendix wall perforation and the presence of mucin, cells, or both outside the appendix were not associated with a higher risk of metachronous peritoneal dissemination. In this setting, clinical and radiologic surveillance is a viable choice.