Evaluation of antibacterial and modifying action of catechin antibiotics in resistant strains

Diseases caused by bacteria are today one of the great problems of present time. Access to over-the-counter medication, the indiscriminate use of antibacterials and high rates of hospitalization have contributed to the increase in cases. This picture has led to the search for new alternative drugs....

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Bibliographic Details
Published in:Microbial pathogenesis 2018-02, Vol.115, p.175-178
Main Authors: Gomes, Fernanda Mateus Silva, da Cunha Xavier, Jayze, dos Santos, Joycy Francely Sampaio, de Matos, Yedda Maria Lobo Soares, Tintino, Saulo Relison, de Freitas, Thiago Sampaio, Coutinho, Henrique Douglas Melo
Format: Article
Language:English
Subjects:
Antibacterials
Polyphenols
Resistance
Secondary metabolites
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Summary:Diseases caused by bacteria are today one of the great problems of present time. Access to over-the-counter medication, the indiscriminate use of antibacterials and high rates of hospitalization have contributed to the increase in cases. This picture has led to the search for new alternative drugs. Thus, secondary metabolites have been reported as a possible treatment option, being evidenced in many researches to ascertain their combination with existing drugs. This research aimed to evaluate the antibacterial effect and the antibiotic activity modifying action of the catechin compound against Pseudomonas aeruginosa, Escherichia coli and Staphylococcus aureus multiresistant strains. The determination of the Minimum Inhibitory Concentration (MIC) and the evaluation of the antimicrobial and potentiating effect were performed by broth microdilution. The MIC obtained forcatechin against all the used strains was indicated as not clinically relevant. The combination of catechin and antibacterial drugs, both Gram-negative and Gram-positive, was synergistic and antagonistic in some drugs. Therefore, phenolic compounds can assist in the fight against infections caused by bacteria. •Catechin associated with imipenem, tetracycline and erythromycin against E. coli showed a synergistic effect.•Catechin-associated with erythromycin against P. aeruginosa showed an antagonism.•Catechin associated with norfloxacin and gentamicin against S. aureus showed a synergistic effect.
ISSN:0882-4010
1096-1208
DOI:10.1016/j.micpath.2017.12.058