A study about immunomodulatory effect and efficacy and prognosis of human umbilical cord mesenchymal stem cells in patients with chronic hepatitis B‐induced decompensated liver cirrhosis

• Published in: Journal of gastroenterology and hepatology 2018-04, Vol.33 (4), p.774-780
• Main Authors: Fang, Xueqing, Liu, Liwei, Dong, Jing, Zhang, Junfei, Song, Haiyan, Song, Youliang, Huang, Yizhe, Cui, Xiaoling, Lin, Jian, Chen, Congxin, Liu, Bo, Chen, Zhaolin, Pan, Jingjing, Chen, Xi
• Format: Article
• Language: English
• Subjects: Adult; Alanine; Alanine transaminase; Albumin; Aspartate aminotransferase; Aspartate Aminotransferases - blood; Bilirubin; Bilirubin - blood; Biomarkers - blood; Cirrhosis; cytokine; Cytokines; Cytokines - blood; decompensated liver cirrhosis; efficacy; Female; Hepatitis; Hepatitis B; Hepatitis B, Chronic - complications; Humans; Immunomodulation; immunomodulatory; Liver cirrhosis; Liver Cirrhosis - diagnosis; Liver Cirrhosis - etiology; Liver Cirrhosis - immunology; Liver Cirrhosis - therapy; Liver diseases; Lymphocyte Subsets; Lymphocytes B; Lymphocytes T; Male; mesenchymal stem cell; Mesenchymal Stem Cell Transplantation; Mesenchymal stem cells; Mesenchymal Stromal Cells; Mesenchyme; Middle Aged; Prognosis; Prothrombin; Prothrombin Time; Stem cells; Transforming growth factor-b; Transplantation; Treatment Outcome; Tumor necrosis factor-α; Umbilical cord; Umbilical Cord - cytology
• ISSN: 0815-9319; 1440-1746
• DOI: 10.1111/jgh.14081

Background and Aim The aim of our study was to investigate the immunomodulatory effect and short‐term efficacy and long‐term prognosis of decompensated liver cirrhosis patients caused by hepatitis B after a double transplantation with human umbilical cord mesenchymal stem cells (hUCMSCs). Methods Fifty inpatients were recruited and given the same medical treatments, receiving hUCMSCs injection intravenously. Fifty‐three patients (Group B) matched for age, sex, and baseline alanine aminotransferase, aspartate aminotransferase, albumin, total bilirubin, prothrombin time, and model for end‐stage liver disease score and Child–Pugh classification, acted as the control group. Results Interleukin‐6 and tumor necrosis factor alpha levels markedly decreased, and interleukin‐10 level apparently increased in Group A at 2 and 4 weeks after treatment. Transforming growth factor beta in Group A increased more remarkably at 2 weeks after treatment. T4 cells and Treg cells in Group A were apparently higher than those in Group B at 2 and 4 weeks after treatment, and T8 cells and B cells were significantly lower than those in Group B. Aspartate aminotransferase levels in Group A were dramatically declining at 8 and 12 weeks after treatment. Levels of albumin, total bilirubin, and prothrombin time in Group A were apparently improved from 4 to 12 weeks after treatment. The improvements in model for end‐stage liver disease and Child–Pugh scores in Group A were notably superior to those in Group B from 4 to 36 weeks after treatment. There were no remarkable differences in the incidence of developing liver failure throughout the follow‐up period, but the mortality rate of Group A was lower than that of Group B. Conclusion This therapeutic method may be an appropriate choice for patients with decompensated liver cirrhosis.