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Effect of botulinum toxin antral injection on gastric emptying and weight reduction in obese patients: a pilot study

Summary Background  A potential approach to the treatment of morbid obesity is reduction of gastric emptying to achieve satiety. Botulinum toxin A (Btx‐A) is a long‐acting inhibitor of acetylcholine‐mediated peristalsis, which is mainly responsible for gastric motility. Aim  To investigate whether b...

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Published in:Alimentary pharmacology & therapeutics 2006-03, Vol.23 (5), p.675-680
Main Authors: GUI, D., MINGRONE, G., VALENZA, V., SPADA, P. L., MUTIGNANI, M., RUNFOLA, M., SCARFONE, A., MUGNO, M., PANUNZI, S.
Format: Article
Language:English
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Summary:Summary Background  A potential approach to the treatment of morbid obesity is reduction of gastric emptying to achieve satiety. Botulinum toxin A (Btx‐A) is a long‐acting inhibitor of acetylcholine‐mediated peristalsis, which is mainly responsible for gastric motility. Aim  To investigate whether botulinum toxin A, injected in the antrum of obese patients, delays gastric emptying. Methods  In a double_blind study, 18 healthy obese subjects (body mass index >30) were randomized into three groups (BTX133, BTX200 and Saline); they received Btx‐A133U, Btx‐A200U, or saline under endoscopic control. Gastric emptying was tested by scintigraphy before and 10 days after treatment. Body weight variations and appetite sensation were recorded after 5 weeks. Results  Fourteen patients completed the study. The botulinum toxin A‐treated groups showed weight reduction, which was not statistically significant. The effects on gastric emptying were variable. Most of the botulinum toxin A treated patients reported a reduced appetite. Conclusion  This pilot clinical trial suggests potential activity of botulinum toxin A for the manipulation of appetite.
ISSN:0269-2813
1365-2036
DOI:10.1111/j.1365-2036.2006.02773.x