Non-protective immunity against tetanus in primiparous women and newborns at birth in rural and urban settings in Ibadan, Nigeria

Nigeria remains among the few countries that are yet to achieve eradication of neonatal tetanus in the world despite the availability of an effective vaccine. This study investigated immunity against tetanus in primiparous mothers and neonates at birth, and identified associated factors. This cross-...

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Bibliographic Details
Published in:The Pan African medical journal 2017, Vol.27 (Suppl 3), p.26-26
Main Authors: Orimadegun, Adebola Emmanuel, Orimadegun, Bose Etaniamhe, Bamgboye, Elijah Afolabi
Format: Article
Language:English
Subjects:
Adult
Chromatography, Affinity
Cross-Sectional Studies
Data collection
Epidemiology
Fatalities
Female
HIV
Human immunodeficiency virus
Humans
Immunoglobulins
Infant, Newborn
Infant, Newborn, Diseases - immunology
Infant, Newborn, Diseases - prevention & control
Infections
Local government
Logistic Models
Malaria
Male
Mothers
Newborn babies
Nigeria
Pregnancy
Public health
Questionnaires
Rural areas
Rural Population - statistics & numerical data
Sample size
Sampling techniques
Tetanus
Tetanus - immunology
Tetanus - prevention & control
Tetanus Toxoid - administration & dosage
Urban Population - statistics & numerical data
Vaccination
Womens health
Young Adult
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Summary:Nigeria remains among the few countries that are yet to achieve eradication of neonatal tetanus in the world despite the availability of an effective vaccine. This study investigated immunity against tetanus in primiparous mothers and neonates at birth, and identified associated factors. This cross-sectional study involved consecutive selection of 244 primiparous mother-neonate pairs (119 from rural areas, 125 from urban areas, 137 male neonates and 107 female neonates) delivered at primary healthcare facilities in Ibadan, Nigeria Socio-demographic characteristics, obstetric history, immunisation and birthweight were obtained from mothers by interview. A validated immunochromatographic rapid diagnostic test kit was used to test for immunity against tetanus. Positive and negative results were interpreted as protective immunity against tetanus (PIaT) and non-protective immunity against tetanus (NPIaT), respectively. Data were analysed using descriptive statistics, Chi-square and logistic regression at p = 0.05. The mean age of mothers was 27.9±3.4 years (range: 20-33) and median birthweight was 2700g (range: 1760-3300). Of the 244 mothers, 198 (81.1%) received at least two doses of tetanus toxoid injection during pregnancy and prevalence of NPIaT and PIaT was 28.7% and 71.3%, respectively. The prevalence of PIaT was significantly higher among mothers in urban areas (n= 96; 80.7%) than rural (n=78; 62.4%), p
ISSN:1937-8688
1937-8688
DOI:10.11604/PAMJ.SUPP.2017.27.3.11869