Circadian dysfunction and fluctuations in gait initiation impairment in Parkinson’s disease

In people with Parkinson’s disease (PD), anticipatory postural adjustments may be prolonged, reduced in amplitude, or absent, contributing to impaired gait initiation. In addition to motor symptoms, disturbance of the circadian rhythm (CR) is one of the common non-motor symptoms of PD. The purpose o...

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Bibliographic Details
Published in:Experimental brain research 2018-03, Vol.236 (3), p.655-664
Main Authors: Stewart, Julianne, Bachman, Gail, Cooper, Clarissa, Liu, Lianqi, Ancoli-Israel, Sonia, Alibiglou, Laila
Format: Article
Language:English
Subjects:
Actigraphy
Aged
Biomechanical Phenomena
Biomedical and Life Sciences
Biomedicine
Chronobiology Disorders - etiology
Chronobiology Disorders - physiopathology
Circadian rhythm
Circadian rhythms
Diurnal
Female
Gait
Gait Disorders, Neurologic - etiology
Gait Disorders, Neurologic - physiopathology
Health aspects
Humans
Male
Middle Aged
Movement disorders
Neurodegenerative diseases
Neurology
Neurosciences
Parkinson disease
Parkinson Disease - complications
Parkinson Disease - physiopathology
Parkinson's disease
Physiological aspects
Postural Balance - physiology
Posture
Rehabilitation
Research Article
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Summary:In people with Parkinson’s disease (PD), anticipatory postural adjustments may be prolonged, reduced in amplitude, or absent, contributing to impaired gait initiation. In addition to motor symptoms, disturbance of the circadian rhythm (CR) is one of the common non-motor symptoms of PD. The purpose of this study was to investigate whether time of day modulates the magnitude of gait initiation impairment, and furthermore, if there is any relationship between CR dysfunction and impaired postural control in PD. Seven consecutive 24-h periods of wrist actigraphy (as a measure of CR), and then gait initiation studies (at two different times, 9:00 a.m. and 2:30 p.m., of the same day) were conducted in two cohorts of ten subjects each: people with PD, and age-matched control subjects. We found that in the PD group, the amplitude of medial/lateral center of pressure (CoP) excursions were significantly reduced in the afternoon as compared with the morning session across all trials ( p  
ISSN:0014-4819
1432-1106
DOI:10.1007/s00221-017-5163-5