Loading…
Synthesis and structure–activity relationship study of diaryl[d,f][1,3]diazepines as potential anti-cancer agents
We herein report the synthesis, biological activity and preliminary structure–activity relationships of a series of diaryl[1,3]diazepines. These compounds were able to inhibit the proliferation of many cancer cell lines, such as HeLa, MCF-7, SGC7901 and A549. When HeLa cells were treated with lead c...
Saved in:
| Published in: | Molecular diversity 2018-05, Vol.22 (2), p.323-333 |
|---|---|
| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c372t-dd58d29f119348ee6146caf0259dc820fa67b9e4390daeb0211dffaab3c6c3a13 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c372t-dd58d29f119348ee6146caf0259dc820fa67b9e4390daeb0211dffaab3c6c3a13 |
| container_end_page | 333 |
| container_issue | 2 |
| container_start_page | 323 |
| container_title | Molecular diversity |
| container_volume | 22 |
| creator | Yan, Longjia Wang, Hui Chen, Yunpeng Li, Zhiwei Pei, Yazhong |
| description | We herein report the synthesis, biological activity and preliminary structure–activity relationships of a series of diaryl[1,3]diazepines. These compounds were able to inhibit the proliferation of many cancer cell lines, such as HeLa, MCF-7, SGC7901 and A549. When HeLa cells were treated with lead compounds
7j
and
7k
at 3
μ
M
concentration, cell arrest was observed in the G2/M phase.
Graphical Abstract |
| doi_str_mv | 10.1007/s11030-017-9805-0 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1984751341</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1983982460</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-dd58d29f119348ee6146caf0259dc820fa67b9e4390daeb0211dffaab3c6c3a13</originalsourceid><addsrcrecordid>eNp1kc1KHTEYhkOpVGt7Ad2UgW5cmJovmb8si9RWELrQQkEk5CRfNDInM00yhePKe-gdeiVmOFZKoav8Pe-TkJeQd8A-AmPdUQJgglEGHZU9ayh7Qfag6QRtGPx4WeaiBwpSwi55ndItYyUF4hXZ5ZJL2TfdHknnm5BvMPlU6WCrlONs8hzx4f63Ntn_8nlTRRx09mNIN34qxGw31egq63XcDJf20F1dwqG4Kus7nHzAYkrVNGYM2euhaLOnRgeDsdLXZTO9ITtODwnfPo375PvJ54vjr_Ts25fT409n1IiOZ2pt01suHYAUdY_YQt0a7RhvpDU9Z0633UpiLSSzGleMA1jntF4J0xqhQeyTg613iuPPGVNWa58MDoMOOM5JgezrrgFRL-iHf9DbcY6hvG6hhOx53bJCwZYycUwpolNT9OvyDQqYWhpR20ZUaUQtjagl8_7JPK_WaJ8TfyooAN8CqRyFa4x_Xf1f6yPVOZlR</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1983982460</pqid></control><display><type>article</type><title>Synthesis and structure–activity relationship study of diaryl[d,f][1,3]diazepines as potential anti-cancer agents</title><source>Springer Nature</source><creator>Yan, Longjia ; Wang, Hui ; Chen, Yunpeng ; Li, Zhiwei ; Pei, Yazhong</creator><creatorcontrib>Yan, Longjia ; Wang, Hui ; Chen, Yunpeng ; Li, Zhiwei ; Pei, Yazhong</creatorcontrib><description>We herein report the synthesis, biological activity and preliminary structure–activity relationships of a series of diaryl[1,3]diazepines. These compounds were able to inhibit the proliferation of many cancer cell lines, such as HeLa, MCF-7, SGC7901 and A549. When HeLa cells were treated with lead compounds
7j
and
7k
at 3
μ
M
concentration, cell arrest was observed in the G2/M phase.
Graphical Abstract</description><identifier>ISSN: 1381-1991</identifier><identifier>EISSN: 1573-501X</identifier><identifier>DOI: 10.1007/s11030-017-9805-0</identifier><identifier>PMID: 29299857</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Antineoplastic Agents - chemical synthesis ; Antineoplastic Agents - chemistry ; Antineoplastic Agents - pharmacology ; Azepines - chemical synthesis ; Azepines - chemistry ; Azepines - pharmacology ; Biochemistry ; Biomedical and Life Sciences ; Cancer therapies ; Cellular biology ; Chemical compounds ; Chemical synthesis ; Chemistry Techniques, Synthetic ; HeLa Cells ; Humans ; Life Sciences ; Molecular structure ; Organic Chemistry ; Original Article ; Pharmacy ; Polymer Sciences ; Structure-Activity Relationship</subject><ispartof>Molecular diversity, 2018-05, Vol.22 (2), p.323-333</ispartof><rights>Springer International Publishing AG, part of Springer Nature 2018</rights><rights>Molecular Diversity is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-dd58d29f119348ee6146caf0259dc820fa67b9e4390daeb0211dffaab3c6c3a13</citedby><cites>FETCH-LOGICAL-c372t-dd58d29f119348ee6146caf0259dc820fa67b9e4390daeb0211dffaab3c6c3a13</cites><orcidid>0000-0003-3703-6704</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29299857$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yan, Longjia</creatorcontrib><creatorcontrib>Wang, Hui</creatorcontrib><creatorcontrib>Chen, Yunpeng</creatorcontrib><creatorcontrib>Li, Zhiwei</creatorcontrib><creatorcontrib>Pei, Yazhong</creatorcontrib><title>Synthesis and structure–activity relationship study of diaryl[d,f][1,3]diazepines as potential anti-cancer agents</title><title>Molecular diversity</title><addtitle>Mol Divers</addtitle><addtitle>Mol Divers</addtitle><description>We herein report the synthesis, biological activity and preliminary structure–activity relationships of a series of diaryl[1,3]diazepines. These compounds were able to inhibit the proliferation of many cancer cell lines, such as HeLa, MCF-7, SGC7901 and A549. When HeLa cells were treated with lead compounds
7j
and
7k
at 3
μ
M
concentration, cell arrest was observed in the G2/M phase.
Graphical Abstract</description><subject>Antineoplastic Agents - chemical synthesis</subject><subject>Antineoplastic Agents - chemistry</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Azepines - chemical synthesis</subject><subject>Azepines - chemistry</subject><subject>Azepines - pharmacology</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Cancer therapies</subject><subject>Cellular biology</subject><subject>Chemical compounds</subject><subject>Chemical synthesis</subject><subject>Chemistry Techniques, Synthetic</subject><subject>HeLa Cells</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Molecular structure</subject><subject>Organic Chemistry</subject><subject>Original Article</subject><subject>Pharmacy</subject><subject>Polymer Sciences</subject><subject>Structure-Activity Relationship</subject><issn>1381-1991</issn><issn>1573-501X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kc1KHTEYhkOpVGt7Ad2UgW5cmJovmb8si9RWELrQQkEk5CRfNDInM00yhePKe-gdeiVmOFZKoav8Pe-TkJeQd8A-AmPdUQJgglEGHZU9ayh7Qfag6QRtGPx4WeaiBwpSwi55ndItYyUF4hXZ5ZJL2TfdHknnm5BvMPlU6WCrlONs8hzx4f63Ntn_8nlTRRx09mNIN34qxGw31egq63XcDJf20F1dwqG4Kus7nHzAYkrVNGYM2euhaLOnRgeDsdLXZTO9ITtODwnfPo375PvJ54vjr_Ts25fT409n1IiOZ2pt01suHYAUdY_YQt0a7RhvpDU9Z0633UpiLSSzGleMA1jntF4J0xqhQeyTg613iuPPGVNWa58MDoMOOM5JgezrrgFRL-iHf9DbcY6hvG6hhOx53bJCwZYycUwpolNT9OvyDQqYWhpR20ZUaUQtjagl8_7JPK_WaJ8TfyooAN8CqRyFa4x_Xf1f6yPVOZlR</recordid><startdate>20180501</startdate><enddate>20180501</enddate><creator>Yan, Longjia</creator><creator>Wang, Hui</creator><creator>Chen, Yunpeng</creator><creator>Li, Zhiwei</creator><creator>Pei, Yazhong</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3703-6704</orcidid></search><sort><creationdate>20180501</creationdate><title>Synthesis and structure–activity relationship study of diaryl[d,f][1,3]diazepines as potential anti-cancer agents</title><author>Yan, Longjia ; Wang, Hui ; Chen, Yunpeng ; Li, Zhiwei ; Pei, Yazhong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-dd58d29f119348ee6146caf0259dc820fa67b9e4390daeb0211dffaab3c6c3a13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Antineoplastic Agents - chemical synthesis</topic><topic>Antineoplastic Agents - chemistry</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Azepines - chemical synthesis</topic><topic>Azepines - chemistry</topic><topic>Azepines - pharmacology</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Cancer therapies</topic><topic>Cellular biology</topic><topic>Chemical compounds</topic><topic>Chemical synthesis</topic><topic>Chemistry Techniques, Synthetic</topic><topic>HeLa Cells</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Molecular structure</topic><topic>Organic Chemistry</topic><topic>Original Article</topic><topic>Pharmacy</topic><topic>Polymer Sciences</topic><topic>Structure-Activity Relationship</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yan, Longjia</creatorcontrib><creatorcontrib>Wang, Hui</creatorcontrib><creatorcontrib>Chen, Yunpeng</creatorcontrib><creatorcontrib>Li, Zhiwei</creatorcontrib><creatorcontrib>Pei, Yazhong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular diversity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yan, Longjia</au><au>Wang, Hui</au><au>Chen, Yunpeng</au><au>Li, Zhiwei</au><au>Pei, Yazhong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis and structure–activity relationship study of diaryl[d,f][1,3]diazepines as potential anti-cancer agents</atitle><jtitle>Molecular diversity</jtitle><stitle>Mol Divers</stitle><addtitle>Mol Divers</addtitle><date>2018-05-01</date><risdate>2018</risdate><volume>22</volume><issue>2</issue><spage>323</spage><epage>333</epage><pages>323-333</pages><issn>1381-1991</issn><eissn>1573-501X</eissn><abstract>We herein report the synthesis, biological activity and preliminary structure–activity relationships of a series of diaryl[1,3]diazepines. These compounds were able to inhibit the proliferation of many cancer cell lines, such as HeLa, MCF-7, SGC7901 and A549. When HeLa cells were treated with lead compounds
7j
and
7k
at 3
μ
M
concentration, cell arrest was observed in the G2/M phase.
Graphical Abstract</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>29299857</pmid><doi>10.1007/s11030-017-9805-0</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0003-3703-6704</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1381-1991 |
| ispartof | Molecular diversity, 2018-05, Vol.22 (2), p.323-333 |
| issn | 1381-1991 1573-501X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1984751341 |
| source | Springer Nature |
| subjects | Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Azepines - chemical synthesis Azepines - chemistry Azepines - pharmacology Biochemistry Biomedical and Life Sciences Cancer therapies Cellular biology Chemical compounds Chemical synthesis Chemistry Techniques, Synthetic HeLa Cells Humans Life Sciences Molecular structure Organic Chemistry Original Article Pharmacy Polymer Sciences Structure-Activity Relationship |
| title | Synthesis and structure–activity relationship study of diaryl[d,f][1,3]diazepines as potential anti-cancer agents |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T16%3A06%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Synthesis%20and%20structure%E2%80%93activity%20relationship%20study%20of%20diaryl%5Bd,f%5D%5B1,3%5Ddiazepines%20as%20potential%20anti-cancer%20agents&rft.jtitle=Molecular%20diversity&rft.au=Yan,%20Longjia&rft.date=2018-05-01&rft.volume=22&rft.issue=2&rft.spage=323&rft.epage=333&rft.pages=323-333&rft.issn=1381-1991&rft.eissn=1573-501X&rft_id=info:doi/10.1007/s11030-017-9805-0&rft_dat=%3Cproquest_cross%3E1983982460%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c372t-dd58d29f119348ee6146caf0259dc820fa67b9e4390daeb0211dffaab3c6c3a13%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1983982460&rft_id=info:pmid/29299857&rfr_iscdi=true |