Synthesis and spectroscopic characterization of transition metal complexes of a 12-membered tetraaza [N4] macrocyclic ligand and their biological activity

• Published in: Transition metal chemistry (Weinheim) 2007-11, Vol.32 (8), p.1079-1084
• Main Authors: Chandra, Sulekh, Gautam, Archana, Tyagi, Monika
• Format: Article
• Language: English
• Subjects: Ligands
• ISSN: 0340-4285; 1572-901X
• DOI: 10.1007/s11243-007-0289-0

Cobalt(II), nickel(II) and copper(II) complexes are synthesized with 1,3,7,9-tetraaza- 4,6,10,12-tetraphenyl-2,8-dithiacyclododecane, a tetradentate ligand (L) and characterized by elemental analysis, molar conductance measurements, magnetic susceptibitity measurements, mass, i.r., electronic and e.p.r. spectral studies. All the complexes are non-electrolytes so they may be formulated as [M(L)X^sub 2^] [where, M = Co(II), Ni(II) and Cu(II) and X = Cl^sup -^ and NO ^sub 3^ ^sup -^ ]. All the complexes are of high spin type. On the basis of i.r., electronic and e.p.r. spectral studies an octahedral geometry has been assigned for Co(II) and Ni(II) complexes and tetragonal geometry for Cu(II) complexes. The antimicrobial activities of the ligand and its complexes, as growth inhibiting agents, have been screened in vitro against two different species of bacteria and plant pathogenic fungi.[PUBLICATION ABSTRACT]