Neural correlates of instrumental responding in the context of alcohol-related cues index disorder severity and relapse risk

The influence of Pavlovian conditioned stimuli on ongoing behavior may contribute to explaining how alcohol cues stimulate drug seeking and intake. Using a Pavlovian-instrumental transfer task, we investigated the effects of alcohol-related cues on approach behavior (i.e., instrumental response beha...

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Bibliographic Details
Published in:European archives of psychiatry and clinical neuroscience 2019-04, Vol.269 (3), p.295-308
Main Authors: Schad, Daniel J., Garbusow, Maria, Friedel, Eva, Sommer, Christian, Sebold, Miriam, Hägele, Claudia, Bernhardt, Nadine, Nebe, Stephan, Kuitunen-Paul, Sören, Liu, Shuyan, Eichmann, Uta, Beck, Anne, Wittchen, Hans-Ulrich, Walter, Henrik, Sterzer, Philipp, Zimmermann, Ulrich S., Smolka, Michael N., Schlagenhauf, Florian, Huys, Quentin J. M., Heinz, Andreas, Rapp, Michael A.
Format: Article
Language:English
Subjects:
Adult
Alcohol
Alcoholism - diagnostic imaging
Alcoholism - physiopathology
Approach behavior
Behavior
Conditioning, Classical - physiology
Conditioning, Operant - physiology
Cues
Detoxification
Extinction behavior
Female
Follow-Up Studies
Functional magnetic resonance imaging
Humans
Lead
Magnetic Resonance Imaging
Male
Medicine
Medicine & Public Health
Middle Aged
NCT
NCT01679145
Neurosciences
Nucleus accumbens
Nucleus Accumbens - diagnostic imaging
Nucleus Accumbens - physiopathology
Original Paper
Psychiatry
Recurrence
Risk
Severity of Illness Index
Transfer (Psychology) - physiology
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Summary:The influence of Pavlovian conditioned stimuli on ongoing behavior may contribute to explaining how alcohol cues stimulate drug seeking and intake. Using a Pavlovian-instrumental transfer task, we investigated the effects of alcohol-related cues on approach behavior (i.e., instrumental response behavior) and its neural correlates, and related both to the relapse after detoxification in alcohol-dependent patients. Thirty-one recently detoxified alcohol-dependent patients and 24 healthy controls underwent instrumental training, where approach or non-approach towards initially neutral stimuli was reinforced by monetary incentives. Approach behavior was tested during extinction with either alcohol-related or neutral stimuli (as Pavlovian cues) presented in the background during functional magnetic resonance imaging (fMRI). Patients were subsequently followed up for 6 months. We observed that alcohol-related background stimuli inhibited the approach behavior in detoxified alcohol-dependent patients ( t  = − 3.86, p  
ISSN:0940-1334
1433-8491
DOI:10.1007/s00406-017-0860-4