Performance of diffusion-weighted magnetic resonance imaging at 3.0T for early assessment of tumor response in locally advanced rectal cancer treated with preoperative chemoradiation therapy

Purpose The purpose of the article is to determine whether changes in apparent diffusion coefficient (ADC) values of locally advanced rectal cancer (LARC) obtained 2 weeks after the beginning of chemoradiation therapy (CRT) allow to predict treatment response and whether correlate with tumor histopa...

Full description

Saved in:
Bibliographic Details
Published in:Abdominal imaging 2018-09, Vol.43 (9), p.2221-2230
Main Authors: Delli Pizzi, Andrea, Cianci, Roberta, Genovesi, Domenico, Esposito, Gianluigi, Timpani, Mauro, Tavoletta, Alessandra, Pulsone, Pierluigi, Basilico, Raffaella, Gabrielli, Daniela, Rosa, Consuelo, Caravatta, Luciana, Di Tommaso, Monica, Caulo, Massimo, Filippone, Antonella
Format: Article
Language:English
Subjects:
Cancer
Chemoradiotherapy
Chemotherapy
Colorectal cancer
Correlation
Diagnostic systems
Diffusion
Diffusion coefficient
Gastroenterology
Hepatology
Imaging
Magnetic resonance imaging
Medicine
Medicine & Public Health
NMR
Nuclear magnetic resonance
Quality
Radiation therapy
Radiology
Rectum
Regression analysis
Resonance
Sensitivity
Surgery
Surgical instruments
Therapy
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose The purpose of the article is to determine whether changes in apparent diffusion coefficient (ADC) values of locally advanced rectal cancer (LARC) obtained 2 weeks after the beginning of chemoradiation therapy (CRT) allow to predict treatment response and whether correlate with tumor histopathologic response. Methods Forty-three patients receiving CRT for LARC and 3.0T magnetic resonance imaging with diffusion-weighted sequences before treatment, 2 weeks during, and 8 weeks post the completion of CRT were included. ADC values were calculated at each time point and percentage of ADC changes at 2 weeks (ΔADC during) and 8 weeks (ΔADC post) were assessed. Data were correlated to surgical results and histopathologic tumor regression grade (TRG), according to Mandard’s classification. ADC values and ΔADCs of complete responders (CR; TRG1) and non-complete responders (non-CR; TRG 2-5) were compared. Receiver-operating characteristic curve (ROC) analysis was used to assess diagnostic accuracy of ΔADC for differentiating CR from non-CR. The correlation with TRG was investigated using Spearman's rank test. Results ΔADC during and ΔADC post were significantly higher in CR (33.9% and 57%, respectively) compared to non-CR (13.5% and 2.2%, respectively) group ( p  = 0.006 and p  
ISSN:2366-004X
2366-0058
DOI:10.1007/s00261-018-1457-8