Inflammatory biomarkers and intellectual disability in patients with Down syndrome

Background Intellectual disability (ID) is part of the Down syndrome (DS) phenotypic spectrum, but the exact molecular pathophysiology of ID in individuals with DS is not yet fully understood, with many research hypotheses still unproven. Basing on previous studies (which suggested a possible role o...

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Bibliographic Details
Published in:Journal of intellectual disability research 2018-05, Vol.62 (5), p.382-390
Main Authors: Manti, S., Cutrupi, M. C., Cuppari, C., Ferro, E., Dipasquale, V., Di Rosa, G., Chimenz, R., La Rosa, M. A., Valenti, A., Salpietro, V.
Format: Article
Language:English
Subjects:
Biological markers
Biomarkers
children
Control Groups
Correlation
Correlation analysis
C‐reactive protein
Down Syndrome
high mobility group box‐1
Intellectual disabilities
Intellectual Disability
intellectual quotient
Intelligence Quotient
Intelligence tests
Learning disabilities
Mobility
Pathophysiology
Serum
serum amyloid A
Severity
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Summary:Background Intellectual disability (ID) is part of the Down syndrome (DS) phenotypic spectrum, but the exact molecular pathophysiology of ID in individuals with DS is not yet fully understood, with many research hypotheses still unproven. Basing on previous studies (which suggested a possible role of altered inflammatory response in DS‐related ID), we assessed the serum levels of a number of inflammatory biomarkers [serum amyloid A (SAA), C‐reactive protein (C‐RP), high mobility group box‐1 (HMGB1)] in a cohort of individuals with DS and healthy controls. Methods In total, 24 children diagnosed with DS and 12 healthy controls were enrolled, and all underwent detailed cognitive assessment. Also, serum SAA, C‐RP and HMGB1 levels were measured in all recruited subjects and correlated to the severity of ID in the DS group. Results Serum SAA, C‐RP and HMGB1 values were found to be significantly higher in the DS group compared with the healthy subjects (P = 0.001). In addition, serum HMGB1 levels positively correlated with C‐RP and SAA in the DS group but not in the healthy controls. Only serum C‐RP levels resulted inversely correlated (P  0.05). Conclusions The levels of the determined markers were higher in DS individuals compared with (cognitively) healthy subjects, and CRP showed a negative correlation with IQ in children with DS.
ISSN:0964-2633
1365-2788
DOI:10.1111/jir.12470