Patent foramen ovale repair at the time of double lung transplantation: Necessary or not?

• Published in: Clinical transplantation 2018-04, Vol.32 (4), p.e13201-e13201
• Main Authors: Hess, Nicholas R, Esper, Stephen A, Awori Hayanga, J W, Tuft, Marie, Morrell, Matthew, D'Cunha, Jonathan
• Format: Article
• Language: English
• ISSN: 0902-0063; 1399-0012
• DOI: 10.1111/CTR.13201

Patient foramen ovale (PFO) is a common and often incidental intraoperative finding during lung transplantation (LTx). We sought to characterize the potential outcomes related to the decision making of whether the PFO was repaired or left unrepaired. We retrospectively evaluated bilateral LTx recipients between 2005 and 2015 from our prospective database. Incidence of postoperative stoke, 90-day mortality, and overall survival was compared between the PFO-positive and PFO-negative groups, and secondly compared between repaired PFO (rPFO) and non-repaired PFO (nrPFO) groups. A total of 831 LTx recipients were analyzed: 185 PFO-positive (140 nrPFO, 45 rPFO) and 646 PFO-negative. Study groups were similar with regard to age and comorbidity. The presence of PFO was not associated with a difference in postoperative stroke (P = .89) or 90-day mortality (P = .64). In patients with PFO, intraoperative repair resulted in a lower, but non-significant rate of stroke (0% vs 5%; P = .20) and no difference in mortality (P = .26). As expected, PFO and PFO repair were both associated with a higher incidence of cardiopulmonary bypass utilization, but no difference in pump-related complications. The protective effect of PFO repair remains unclear. However, it is not associated with an increased incidence of stroke or postoperative mortality following LTx.