Invasion and translocation of uropathogenic Escherichia coli isolated from urosepsis and patients with community-acquired urinary tract infection

Uropathogenic Escherichia coli (UPEC) strains are found in high numbers in the gut of patients with urinary tract infections (UTIs). We hypothesised that in hospitalised patients, UPEC strains might translocate from the gut to the blood stream and that this could be due to the presence of virulence...

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Bibliographic Details
Published in:European journal of clinical microbiology & infectious diseases 2018-05, Vol.37 (5), p.833-839
Main Authors: Owrangi, B., Masters, N., Kuballa, A., O’Dea, C., Vollmerhausen, T. L., Katouli, M.
Format: Article
Language:English
Subjects:
Adhesion tests
Bacteria
Biomedical and Life Sciences
Biomedicine
Blood
Communities
E coli
Epithelium
Escherichia coli
Internal Medicine
Medical Microbiology
Original Article
Patients
Translocation
Urinary tract
Urinary tract infections
Urogenital system
Virulence
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Summary:Uropathogenic Escherichia coli (UPEC) strains are found in high numbers in the gut of patients with urinary tract infections (UTIs). We hypothesised that in hospitalised patients, UPEC strains might translocate from the gut to the blood stream and that this could be due to the presence of virulence genes (VGs) that are not commonly found in UPEC strains that cause UTI only. To test this, E. coli strains representing 75 dominant clonal groups of UPEC isolated from the blood of hospitalised patients with UTI (urosepsis) ( n  = 22), hospital-acquired (HA) UTI without blood infection ( n  = 24) and strains isolated from patients with community-acquired (CA)-UTIs ( n  = 29) were tested for their adhesion to, invasion and translocation through Caco-2 cells, in addition to the presence of 34 VGs associated with UPEC. Although there were no differences in the rate and degree of translocation among the groups, urosepsis and HA-UTI strains showed significantly higher abilities to adhere ( P  = 0.0095 and P  
ISSN:0934-9723
1435-4373
DOI:10.1007/s10096-017-3176-4