Daily cycle in hepatic lipid metabolism in obese mice, Neotomodon alstoni: Sex differences

Disruption of circadian rhythms influences the pathogenesis of obesity, particularly with the basic regulation of food intake and metabolism. A link between metabolism and the circadian clock is the peroxisome proliferator-activated receptors (PPARs). The Neotomodon alstoni mouse, known as the "...

Full description

Saved in:
Bibliographic Details
Published in:Chronobiology international 2018-05, Vol.35 (5), p.643-657
Main Authors: Pérez-Mendoza, Moisés, Rivera-Zavala, Julieta Berenice, Rodríguez-Guadarrama, Asael H, Montoya-Gomez, Luis M, Carmona-Castro, Agustín, Díaz-Muñoz, Mauricio, Miranda-Anaya, Manuel
Format: Article
Language:English
Subjects:
Animals
ARNTL Transcription Factors - metabolism
Carnitine O-Palmitoyltransferase - metabolism
Circadian Rhythm
Disease Models, Animal
Fatty Acids, Nonesterified - metabolism
Female
Lipid Metabolism
Liver - metabolism
Male
Obesity - metabolism
Obesity - physiopathology
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - metabolism
Peroxisome Proliferator-Activated Receptors - metabolism
Sex Factors
Sigmodontinae
Sterol Regulatory Element Binding Protein 1 - metabolism
Time Factors
Triglycerides - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Disruption of circadian rhythms influences the pathogenesis of obesity, particularly with the basic regulation of food intake and metabolism. A link between metabolism and the circadian clock is the peroxisome proliferator-activated receptors (PPARs). The Neotomodon alstoni mouse, known as the "Mexican volcano mouse," may develop obesity if fed a normo-caloric diet. This manuscript documents the changes in part of the hepatic lipid homeostasis in both sexes of lean and obese N. alstoni mice, comparing the daily changes in the BMAL1 clock protein, in regulators of lipid metabolism (PGC-1α, PPARα-γ, SREBP-1c, and CPT-1α) and in free fatty acid (FFA) and hepatic triacylglyceride (TAG) metabolites in light-dark cycles. Hepatic tissue and blood were collected at 5, 10, 15, 19, and 24 h. Samples were analyzed by western blotting to determine the relative presence of protein. The results indicate that obesity affects daily changes in lipid metabolism and the BMAL1 profile in females considerably more than in males. These results suggest that the impact of obesity on lipid metabolism has important differences according to sex.
ISSN:0742-0528
1525-6073
DOI:10.1080/07420528.2018.1424178