Validation of estimated glomerular filtration rate equations for Japanese children

Background The gold standard for evaluation of kidney function is renal inulin clearance (Cin). However, the methodology for Cin is complicated and difficult, especially for younger children and/or patients with bladder dysfunction. Therefore, we developed a simple and easier method for obtaining th...

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Bibliographic Details
Published in:Clinical and experimental nephrology 2018-08, Vol.22 (4), p.931-937
Main Authors: Gotoh, Yoshimitsu, Uemura, Osamu, Ishikura, Kenji, Sakai, Tomoyuki, Hamasaki, Yuko, Araki, Yoshinori, Hamda, Riku, Honda, Masataka
Format: Article
Language:English
Subjects:
Adolescent
Child
Child, Preschool
Children
Creatinine
Cystatin C
Epidermal growth factor receptors
Female
Glomerular Filtration Rate
Humans
Infant
Inulin
Japan
Kidney Function Tests
Male
Mathematical models
Medicine
Medicine & Public Health
Nephrology
Original Article
Patients
Reference Values
Renal function
Renal Insufficiency, Chronic - diagnosis
Urinary bladder
Urology
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Summary:Background The gold standard for evaluation of kidney function is renal inulin clearance (Cin). However, the methodology for Cin is complicated and difficult, especially for younger children and/or patients with bladder dysfunction. Therefore, we developed a simple and easier method for obtaining the estimated glomerular filtration rate (eGFR) using equations and values for several biomarkers, i.e., serum creatinine (Cr), serum cystatin C (cystC), serum beta-2 microglobulin (β 2 MG), and creatinine clearance (Ccr). The purpose of the present study was to validate these equations with a new data set. Methods To validate each equation, we used data of 140 patients with CKD with clinical need for Cin, using the measured GFR (mGFR). We compared the results for each eGFR equation with the mGFR using mean error (ME), root mean square error (RMSE), P 30 , and Bland–Altman analysis. Results The ME of Cr, cystC, β 2 MG, and Ccr based on eGFR was 15.8 ± 13.0, 17.2 ± 16.5, 15.4 ± 14.3, and 10.6 ± 13.0 ml/min/1.73 m 2 , respectively. The RMSE was 29.5, 23.8, 20.9, and 16.7, respectively. The P 30 was 79.4, 71.1, 69.5, and 92.9%, respectively. The Bland–Altman bias analysis showed values of 4.0 ± 18.6, 5.3 ± 16.8, 12.7 ± 17.0, and 2.5 ± 17.2 ml/min/1.73 m 2 , respectively, for these parameters. Conclusion The bias of each eGFR equation was not large. Therefore, each eGFR equation could be used.
ISSN:1342-1751
1437-7799
DOI:10.1007/s10157-018-1529-7